NDLI: Mychonastes sp. 247 Induces Apoptosis of A549 Human Lung Cancer Cells by Promoting STRA6-Mediated Reactive Oxygen Species Production

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Mychonastes sp. 247 Induces Apoptosis of A549 Human Lung Cancer Cells by Promoting STRA6-Mediated Reactive Oxygen Species Production

Content Provider	SAGE Publishing
Author	Lee, Soon Hong, Eunmi Yim, Kyung June Jung, Ji Yong Choi, Yong-Soo Lee, Chang Soo Jang, Hyun-Jin Kim, Z-Hun
Copyright Year	2023
Abstract	Mychonastes sp. 247 is a newly isolated freshwater microalga. Mychonastes sp. 247 methanolic extract (ME) suppresses the growth of A549 human non-small-cell lung cancer (NSCLC) cells. However, the underlying mechanism of this anticancer effect remains unclear. The present study aimed to reveal the underlying mechanism of the anticancer effect of ME in A549 cells. The components of ME, their cytotoxicity in normal cells, and their inhibitory effect on the growth and migration of two-dimensional and three-dimensional cultured cancer cells were investigated. We also showed that ME upregulated the mRNA levels of signaling receptors and transporters of retinol (STRA6) and cytochrome P450 family 26 subfamily B member 1, and increased the protein expression of phosphorylated c-Jun N-terminal kinase, B-cell lymphoma protein 2/(Bcl-2)-associated X (Bcl-2/Bax), and cleaved caspase-3. Moreover, co-treatment with N-acetyl-L-cysteine reversed the ME-induced changes in the levels of STRA6 and reactive oxygen species (ROS), confirming their role in the ME-mediated anticancer effect. To the best of our knowledge, this is the first study elucidating the pathway by which ME induces anticancer effects in lung cancer cells. Our results reveal that ME induces NSCLC apoptosis by regulating ROS levels via the STRA6 pathway, suggesting ME as a prospective anticancer agent for lung cancer treatment.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/1934578X231184140?download=true
ISSN	1934578X
Issue Number	7
Volume Number	18
Journal	Natural Product Communications (NPX)
e-ISSN	15559475
DOI	10.1177/1934578X231184140
Language	English
Publisher	Sage Publications CA
Publisher Date	2023-07-16
Publisher Place	Los Angeles
Access Restriction	Open
Rights Holder	© The Author(s) 2023
Subject Keyword	STRA6 A549 ROS apoptosis lung cancer Mychonastes sp. 247 bioactivity
Content Type	Text
Resource Type	Article
Subject	Plant Science Drug Discovery Pharmacology Complementary and Alternative Medicine

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