NDLI: Circulating endothelial progenitor cells in women with gestational alterations of glucose tolerance

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Circulating endothelial progenitor cells in women with gestational alterations of glucose tolerance

Content Provider	SAGE Publishing
Author	Penno, Giuseppe Pucci, Laura Lucchesi, Daniela Lencioni, Cristina Iorio, Maria Carla Vanacore, Renato Storti, Eugenia Resi, Veronica Cianni, Graziano Di Prato, Stefano Del
Copyright Year	2011
Abstract	Endothelial progenitor cells (EPCs) play a role in angiogenesis during pregnancy. The aim of this study was to evaluate circulating EPCs in pregnant women with gestational alterations of glucose tolerance. Glucose tolerance, insulin sensitivity and β-cell function were derived from oral glucose tolerance tests in 23 women with normal glucose tolerance (NGT), 18 with gestational impaired glucose tolerance (GIGT) and 24 with gestational diabetes mellitus (GDM). Circulating cells expressing CD34 in combination with CD133, kinase insert domain receptor (KDR) or both were quantified by flow cytometry. Women with GIGT and GDM had lower CD34+KDR+ and CD34+CD133 +KDR+ cells at 27±3.2 weeks’ gestation compared with NGT (ANOVA p<0.02 for both). CD34+KDR+ and CD34+CD133+KDR+ cells were inversely correlated with the area-under-the-glucose-curve (p<0.005, for both) and positively to insulin secretion-sensitivity index (p<0.05, for both). Alterations of glucose tolerance during pregnancy are associated with a decrease in EPCs. Hyperglycaemia might exert a direct effect on depletion of EPCs.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/1479164111408938?download=true
Starting Page	202
Ending Page	210
Page Count	9
ISSN	14791641
Issue Number	3
Volume Number	8
Journal	Diabetes and Vascular Disease Research (DVR)
e-ISSN	17528984
DOI	10.1177/1479164111408938
Language	English
Publisher	Sage Publications UK
Publisher Date	2011-06-08
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Author(s) 2011
Subject Keyword	pregnancy gestational dysglycaemia endothelial progenitor cells diabetes mellitus
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Cardiology and Cardiovascular Medicine

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