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Proinsulin in pregnant women with normal glucose tolerance or mild gestational diabetes mellitus
| Content Provider | Scilit |
|---|---|
| Author | Festa, A. Shnawa, N. Schernthaner, G. Haffner, S. |
| Copyright Year | 1999 |
| Description | Pregnancy is characterized by peripheral insulin resistance, which is physiologically compensated by an increase in insulin secretion. Type 2 diabetes and impaired glucose tolerance (IGT) have been associated with an inappropriate increase in insulin precursors, namely proinsulin. The aim of this study was to determine levels of proinsulin (PI), specific insulin (SI) and the proinsulin-tospecific insulin (P1/SI) ratio in consecutive pregnant women (n=209) with normal glucose tolerance (NGT), as assessed by a 2horal glucose tolerance test, and with mild gestational diabetes (GDM), in comparison to 32 healthy, non-pregnant women. Furthermore, we related these variables to surrogate markers of insulin resistance and insulin secretion. We found no significant differences in the levels of PI and the PI/SI ratio between pregnant and non-pregnant women (PI: 5.0 ± 3.6vs. 4.8 ± 3.5 pmol/L, p = NS), and between pregnant women with mild GDM and NGT (PI: 5.4 ± 2.4 vs. 4.9 ± 3.9 pmol/L, p =NS). SI was elevated in women with mild GDM (112.2 ± 47.3 vs 94.8 ± 43.0 pmol/L in NGT, p=0.02). PI was related to fasting glucose (r = 0.17, p < 0.02), but not post—load glucose levels, and to fasting insulin [specific insulin: r = 0.67, p = 0.0001; total immunoreactive insulin (tRI): r = 0.69, p = 0.0001], as well as post—load insulin levels (IRI at 120 mm: r = 0.18, p < 0.03). The PI |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0029-1212136.pdf |
| Ending Page | 452 |
| Page Count | 6 |
| Starting Page | 447 |
| ISSN | 09477349 |
| e-ISSN | 14393646 |
| DOI | 10.1055/s-0029-1212136 |
| Journal | Experimental and Clinical Endocrinology & Diabetes |
| Issue Number | 07 |
| Volume Number | 107 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1999-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Experimental and Clinical Endocrinology & Diabetes Medical Laboratory Technology Glucose Tolerance Gestational Diabetes Mellitus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
