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Clinical efficacy of high-dose dexamethasone with sequential prednisone maintenance therapy for newly diagnosed adult immune thrombocytopenia in a real-world setting
| Content Provider | SAGE Publishing |
|---|---|
| Author | Xu, Jin Zhang, Xinhui Feng, Shanglong Zhao, Na Hu, Xin Cheng, Yaxin Wu, Yue Zhou, Li Tong, Juan Zheng, Changcheng |
| Copyright Year | 2021 |
| Abstract | ObjectiveAs first-line treatments for newly diagnosed adult immune thrombocytopenia (ITP), high-dose dexamethasone (HD-DXM) and conventional-dose prednisone achieve good initial responses, but their long-term efficacy is poor. To improve the long-term outcome of newly diagnosed ITP, we explored the efficacy and safety of HD-DXM with sequential prednisone maintenance therapy.MethodsThis retrospective study in a real-world setting assessed 72 consecutive newly diagnosed ITP patients administered first-line HD-DXM with sequential prednisone maintenance therapy from 1 June 2016 to 31 December 2019.ResultsSeventy patients obtained response (97.2%), and 55 achieved sustained response (SR) (76.4%). Fifty-three obtained complete remission (CR) (73.6%), and 39 achieved continuous CR at 6 months (54.2%). Among 36 anti-nuclear antibody-positive patients, 100% achieved response, and 28 achieved CR (77.8%). Among 24 antithyroid antibody-positive patients, 23 (95.8%) achieved response, and 20 achieved CR (83.3%). For patients with initial response, the 12-month probability of SR was 78.6%. For patients with initial CR, the 12-month probability of continuous CR was 64.2%. At 12 months, 21.4% of patients with initial response and 11.3% of patients with initial CR showed loss of treatment response.ConclusionsHD-DXM with sequential prednisone as the first-line treatment for newly diagnosed ITP patients may achieve good clinical efficacy. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/03000605211007322?download=true |
| ISSN | 03000605 |
| Issue Number | 4 |
| Volume Number | 49 |
| Journal | Journal of International Medical Research (IMR) |
| e-ISSN | 14732300 |
| DOI | 10.1177/03000605211007322 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2021-04-12 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2021 |
| Subject Keyword | immune thrombocytopenia real-world setting first-line treatment autoimmune disease Dexamethasone prednisone |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Cell Biology Biochemistry |
