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A DEHP plasticizer alters synaptic proteins via peroxidation

Content Provider	Royal Society of Chemistry (RSC)
Author	Li, Yuan Liu, Chao Liao, Xiaomei Wang, Shaohui Zhang, Pengyan Liu, Ruifang
Copyright Year	2017
Abstract	Di-(2-ethylhexyl) phthalate (DEHP) is a widely used commercial plasticizer. DEHP exposure has a negative impact on brain development and cognition, but the mechanisms responsible for DEHP-induced neurotoxicity are not well understood. Here we showed that DEHP exposure increased maleic dialdehyde and reactive oxygen species contents and decreased endogenous superoxide dismutase activity in a mouse neuroblastoma cell line (N2a cell line). DEHP exposure not only induced reduction of neurite outgrowth, but also led to microtubule-associated protein tau hyperphosphorylation and dissociation from microtubules. Furthermore, DEHP exposure decreased the levels of synapsin-1 and postsynaptic density protein 95 (PSD95), which play critical roles in synaptic function. Antioxidant vitamin E pretreatment prevented DEHP-induced abnormalities in the cells. These results indicate that DEHP exposure could induce abnormal action of proteins including tau, synapsin-1 and PSD95, which play critical roles in the synaptic structure and function, and that these alterations might be mediated by peroxidative damage.
Starting Page	89
Ending Page	97
Page Count	9
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	6
Issue Number	1
Journal	Toxicology Research
DOI	10.1039/c6tx00361c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Reactive oxygen species Neurite Superoxide dismutase Phthalate Neuroblastoma Dissociative Microtubule-associated protein Antioxidant Bis(2-ethylhexyl) phthalate Protein Neurotoxicity Plasticizer Mouse Synapsin DLG4 Vitamin E Postsynaptic density
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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A DEHP plasticizer alters synaptic proteins via peroxidation

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A DEHP plasticizer alters synaptic proteins via peroxidation