NDLI: Application research on PPARα-transgenic mice in preclinical safety evaluation of gemfibrozil

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Application research on PPARα-transgenic mice in preclinical safety evaluation of gemfibrozil

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Toxicology Research Vol -5

Toxicology Research Vol -4

Toxicology Research Vol -3

Toxicology Research Vol -2

Toxicology Research Vol -1

Application research on PPARα-transgenic mice in preclinical safety evaluation of gemfibrozil

Content Provider	Royal Society of Chemistry (RSC)
Author	Mao, Hongmei Li, Xiaocen Li, Yan He, Jun Xu, Yanfeng Wu, Xin Li, Yang Pan, Lishan Li, Yi
Copyright Year	2017
Abstract	To explore the feasibility of peroxisome proliferator-activated receptor (PPAR)α transgenic mice applying in preclinical safety evaluation for peroxisome proliferators (PPs). Both PPARα transgenic mice and C57BL/6J mice were assigned as treated groups (PT and CT groups) and control groups (PC and CC groups). Gemfibrozil was administered into treated groups for 4 weeks. Body weight, blood biochemistry, enzyme activity and histological examinations were performed at scheduled time. The results showed that significant hypolipidaemic effects were induced in the treated groups after gemfibrozil treatment whereas the changes of non-esterified fatty acid and high density lipoproteincholesterol were different between the two treated groups. All the enzyme activities examined increased significantly in PT and CT groups except catalase which displayed no obvious change in the PT group. Pathology results showed a significant increase of the liver weight and the liver weight ratio in the CT group while no obvious changes were observed in the PT group. Hypertrophy of hepatocytes was discovered in CT and PT groups in histological examination, while the extent and incidence of hepatocyte hypertrophy in the CT group were higher than those in the PT group. The data suggest that PPARα transgenic mice could serve as a useful tool for preclinical safety assessment of PP drugs.
Starting Page	98
Ending Page	104
Page Count	7
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	6
Issue Number	1
Journal	Toxicology Research
DOI	10.1039/c6tx00271d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Estrogen receptor Personal computer Peroxisome proliferator-activated receptor Catalase Hepatocyte Enzyme Gemfibrozil Fatty acid Liver Peroxisome Biochemistry Hypertrophy
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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Application research on PPARα-transgenic mice in preclinical safety evaluation of gemfibrozil