NDLI: The toxicological assessment of two anti-obesity drugs in C. elegans

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The toxicological assessment of two anti-obesity drugs in C. elegans

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Toxicology Research Vol - 2 Issue - 1

Toxicology Research Vol -1

The toxicological assessment of two anti-obesity drugs in C. elegans

Content Provider	Royal Society of Chemistry (RSC)
Author	Stürzenbaum, Stephen R. Aitlhadj, Layla
Copyright Year	2013
Abstract	Obesity is an ever increasing health concern of global importance. The treatment options for this condition are limited and until recently there was only one FDA approved anti-obesity drug available. The approval of two anti-obesity drugs which have both undergone post-marketing withdrawal undermines consumer confidence and highlights the need for more robust pre-clinical toxicity testing. The nematode Caenorhabditis elegans is an established toxicological model and while it is still in its infancy with regards to the study of obesity, the ease of maintenance and high-throughput assays makes C. elegans an appealing choice. Here, we explore the suitability of C. elegans as an in vivo toxicity model for the mechanistic screening of two anti-obesity drugs. Toxicity profiles identified that a Sibutramine containing drug induced pronounced effects on pharyngeal pumping, defecation, locomotion and reproduction, in concert indicative of a possible neuronal mode of action. Resultant from a drug resistance screen we demonstrate that Sibutramine has non-serotonergic targets, a notion that suggests that serotonin-specific reuptake inhibitors (SSRIs) are less specific than first assumed. These results stress that the interplay between serotonin, dopamine and norepinephrine is not easily dissected. Overall, the data highlight the value of C. elegans as an in vivo toxicity tool in anti-obesity drug research.
Starting Page	145
Ending Page	150
Page Count	6
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	2
Issue Number	2
Journal	Toxicology Research
DOI	10.1039/c2tx20096a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Obesity FDA Dopamine Serotonin Independent Community and Health Concern Reuptake Sibutramine Anti-obesity medication Pharynx Caenorhabditis elegans Staurogyne elegans Interplay Entertainment Norepinephrine Defecation
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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