NDLI: Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway

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Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway

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Toxicology Research Vol -4

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Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway

Content Provider	Royal Society of Chemistry (RSC)
Author	Shang, Hong-Cai Leng, Chang-Long Li, Xiao-Jun Zhu, Li-Hua Zhang, Wei Kevin Li, Yu-Sang Chen, Man-Tang Tang, He-Bin
Copyright Year	2016
Abstract	It has been reported that massive levels or/and high frequency exposure of diethylnitrosamine could induce hepatic neoplasm. However, it would be more interesting to figure out the hepatotoxic effects of diethylnitrosamine exposure at trace level and low frequency, which could be more common in our daily life. We found that both the mRNA and protein expression levels of β-catenin were aberrant in all liver tissues, accompanied by inflammation, steatosis, fibrosis and hepatic neoplasm after 10-week exposure of diethylnitrosamine (dissolved in sesame oil, 0.16 mmol per kg body weight) to mice. In addition, gradual increase in the mRNA expression of several pivotal risk factors (TNF-α, COX-2, PPAR-γ, AP-2, Smad-2, TGF-β1, and C-myc), as well as their protein expression levels, were associated with the aberrant expression or/and nucleus localization of β-catenin. Altogether, our results show that long-term diethylnitrosamine exposure at trace amounts and low frequency can also induce hepatotoxicity (including inflammation, steatosis and fibrosis) and consequently aberrant activation of β-catenin which in turn plays an important role in the initiation and promotion of liver tumors.
Starting Page	210
Ending Page	223
Page Count	14
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	5
Issue Number	1
Journal	Toxicology Research
DOI	10.1039/c5tx00317b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Liver Inflammation Protein Steatosis Tumor necrosis factor alpha Messenger RNA Prostaglandin-endoperoxide synthase 2 Peroxisome proliferator-activated receptor Beta-catenin Myc Fibrosis Sesame oil Hepatotoxicity N-Nitrosodiethylamine
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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