NDLI: Evaluation of zinc-doped magnetite nanoparticle toxicity in the liver and kidney of mice after sub-chronic intragastric administration

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Toxicology Research Vol -4

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Toxicology Research Vol -1

Evaluation of zinc-doped magnetite nanoparticle toxicity in the liver and kidney of mice after sub-chronic intragastric administration

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Xue Xu, Xiaolong Rong, Rui Zhu, Shanshan Li, Bing
Copyright Year	2016
Abstract	Super-paramagnetic iron oxide nanoparticles (SPIONs) have been approved for clinical use due to their salient super-paramagnetic properties and low toxicity. Zn2+ doped SPIONs possess significantly higher magnetic susceptibility than that of conventional SPIONs. Here we evaluated the potential toxicity of Zn2+ doped Fe3O4 nanoparticles (Zn0.4Fe2.6O4 NPs) in the liver and kidney of mice after repeated intragastric administration for 30 days. Zn0.4Fe2.6O4 NPs did not cause significant changes in their body weights and the coefficients of the liver and kidney, but increased the levels of Fe and Zn in the two organs. Zn0.4Fe2.6O4 NP induced slight oxidative stress in the liver and kidney, which could be successfully counteracted by their intrinsic antioxidant systems and had no observable hazardous effects on the histopathology, ultrastructure and functions of the two organs. These results demonstrated that high-performance magnetic Zn0.4Fe2.6O4 NPs did not produce apparent toxicity in the liver and kidney of mice even after sub-chronic intragastric administration. In addition, Zn2+ doping not only markedly enhanced magnetic susceptibility of Zn0.4Fe2.6O4 NPs but also significantly increased the stability of Zn0.4Fe2.6O4 NPs in biological conditions, making them appropriate for use in magnetic resonance imaging and drug delivery by the oral route.
Starting Page	97
Ending Page	106
Page Count	10
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	5
Issue Number	1
Journal	Toxicology Research
DOI	10.1039/c5tx00292c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Oxidative stress Iron oxide Histopathology Magnetic resonance imaging Ultrastructure Liver Dopant Drug delivery Antioxidant Kidney Magnetic susceptibility
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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