NDLI: Complicity of haem in some adverse drug-reactions

Please wait, while we are loading the content...

A low toxic synthetic dendrimer conjugated podophyllotoxin nanodevice with potent antitumor activity against the DMBA/TPA induced mouse skin carcinogenesis model

p,p′-Dichlorodiphenyltrichloroethane inhibits the apoptosis of colorectal adenocarcinoma DLD1 cells through PI3K/AKT and Hedgehog/Gli1 signaling pathways

Respiratory exposure to single-walled carbon nanotubes induced changes in vascular homeostasis and the expression of peripheral blood related genes in a rat model

Prenatal ethanol exposure induces an intrauterine programming of enhanced sensitivity of the hypothalamic–pituitary–adrenal axis in female offspring rats fed with post-weaning high-fat diet

In vitro effects of low-level aldehyde exposures on human umbilical vein endothelial cells

The role of breast cancer resistance protein (Bcrp/Abcg2) in triptolide-induced testis toxicity

Vitamin E ameliorates neurodegeneration related phenotypes caused by neurotoxicity of Al₂O₃-nanoparticles in C. elegans

Endosulfan inducing blood hypercoagulability and endothelial cells apoptosis via the death receptor pathway in Wistar rats

In vitro toxicological characterisation of arsenic-containing fatty acids and three of their metabolites

Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980–2013

Umbelliferone β-d-galactopyranoside inhibits chemically induced renal carcinogenesis via alteration of oxidative stress, hyperproliferation and inflammation: possible role of NF-κB

Amelioration of mercury nephrotoxicity after pharmacological manipulation of organic anion transporter 1 (Oat1) and multidrug resistance-associated protein 2 (Mrp2) with furosemide

Non-clinical development of ozanezumab: a humanised antibody targeting the amino terminus of neurite outgrowth inhibitor A (Nogo-A)

Palmitic acid induced lipotoxicity is associated with altered lipid metabolism, enhanced CYP450 2E1 and intracellular calcium mediated ER stress in human hepatoma cells

CTAB induced mitochondrial apoptosis by activating the AMPK–p53 pathway in hepatocarcinoma cells

Pathological changes and effect on the learning and memory ability in rats exposed to fluoride and aluminum

Insight into biological system responses in goldfish (Carassius auratus) to multiple doses of avermectin exposure by integrated ¹H NMR-based metabolomics

1,2-Dichloroethane induced nephrotoxicity through ROS mediated apoptosis in vitro and in vivo

Inflammatory cytokine COX-2 mediated cell proliferation through increasing cyclin D1 expression induced by inorganic arsenic in SV-HUC-1 human uroepithelial cells

An experimental and theoretical assessment of quantum dot cytotoxicity

Synthesis and in vivo toxicity assessment of CdSe:ZnS quantum dots functionalized with EDTA-Bis-Cysteamine

Correction: Differential effects of p38 and JNK activation by GSK3 on cadmium-induced autophagy and apoptosis

Correction: Umbelliferone β-d-galactopyranoside exerts an anti-inflammatory effect by attenuating COX-1 and COX-2

Back cover

Toxicology Research Vol - 4 Issue - 4

Toxicology Research Vol - 4 Issue - 3

Toxicology Research Vol - 4 Issue - 2

Toxicology Research Vol - 4 Issue - 1

Toxicology Research Vol -3

Toxicology Research Vol -2

Toxicology Research Vol -1

Complicity of haem in some adverse drug-reactions

Content Provider	Royal Society of Chemistry (RSC)
Author	Vágány, Viktoria Smith, Andrew G.
Copyright Year	2015
Abstract	Adverse drug reactions are often idiosyncratic responses to administered medicines or herbal remedies that may be the consequence of multiple interactions between physiological and genetic factors with drug target and off-target effects. Identification and resolution of the mechanisms of these factors for individuals can prove problematic. Genetic variants or acquired fluctuations in the activity of the haem metabolism enzymes are well established predisposition factors in some known clinical hepatic disorders. Some of these disorders of nonerythroid haem supply can be triggered by drugs, hormones and other agents that normally have no untoward effects. Thus these mutations affecting the activity of the enzymes in the haem pathway can be regarded as predisposing genetic factors causing adverse reactions of some drugs in susceptible individuals. Carriers may be non-symptomatic for a prolonged period until the combination of factors such as consumption of medicinal products, alcohol, stress, hormone fluctuations and change in dietary habits trigger clinical symptoms. Despite these inherited or acquired changes of the haem metabolic pathway, many carriers do not develop symptoms illustrating the involvement of other unknown genetic components. In addition, haem is of fundamental cellular importance not only for respiratory cytochromes and oxygen transport but for many other roles such as for cytochrome P450, NO signalling, and microRNA formation. For these reasons, nonerythroid haem synthesis is under complex transcriptional and translational regulation linked to age, nutrition and circadian rhythm and to hormonal, drug and stress responses. Besides those already known, interference and genetic differences in the flux of supply, recruitment and use of haem for such fundamental processes may contribute to adverse drug reactions in metabolic arenas that are not yet recognised.
Starting Page	1128
Ending Page	1142
Page Count	15
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	4
Issue Number	5
Journal	Toxicology Research
DOI	10.1039/c5tx00011d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Hormone Oxygen MicroRNA Cytochrome P450 Heme Metabolic pathway Adverse drug reaction Circadian rhythm Metabolism
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cytochrome p450 enzyme polymorphisms and adverse drug reactions. Toxicology 2003.

Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.

Inhibition of Cytochrome P450 by Propolis in Human Liver Microsomes.

The Central Role of Cytochrome P450 in Xenobiotic Metabolism—A Brief Review on a Fascinating Enzyme Family

Possible involvement of singlet oxygen species as multiple oxidants in p450 catalytic reactions.

Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects.

Optimization of the bacterial cytochrome p450 bm3 system for the production of human drug metabolites (2012).

Role of cytochrome P450s in the generation and metabolism of reactive oxygen species

Association of Drug Metabolic Enzyme Genetic Polymorphisms and Adverse Drug Reactions in Patients Receiving Rifapentine and Isoniazid Therapy for Latent Tuberculosis.

Complicity of haem in some adverse drug-reactions

Similar Documents

Cytochrome p450 enzyme polymorphisms and adverse drug reactions. Toxicology 2003.

Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.

Inhibition of Cytochrome P450 by Propolis in Human Liver Microsomes.

The Central Role of Cytochrome P450 in Xenobiotic Metabolism—A Brief Review on a Fascinating Enzyme Family

Possible involvement of singlet oxygen species as multiple oxidants in p450 catalytic reactions.

Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects.

Optimization of the bacterial cytochrome p450 bm3 system for the production of human drug metabolites (2012).

Role of cytochrome P450s in the generation and metabolism of reactive oxygen species

Association of Drug Metabolic Enzyme Genetic Polymorphisms and Adverse Drug Reactions in Patients Receiving Rifapentine and Isoniazid Therapy for Latent Tuberculosis.

Complicity of haem in some adverse drug-reactions