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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Muja, Naser Nazhat, Showan N. Quinn, Thomas M. Serpooshan, Vahid |
| Copyright Year | 2011 |
| Abstract | The three dimensional microstructure and fluid conductivity of hydrogels are major determinants of their physical and mechanical properties. Under free fluid flow conditions, highly hydrated fibrillar collagen gels expel fluid and undergo a gravity driven consolidation process (self-compression). Within minutes of the initiation of self-compression, collagen scaffolds with fibrillar densities resembling those of native tissues are produced. However, the microstructural and mechanical processes responsible for collagen gel consolidation have not been fully investigated. During self-compression of collagen gels, a thin, high density lamella of collagen forms at the fluid expulsion boundary thereby generating a two-layer structure. By applying Darcy's law to model fluid flow in the two-layer structure, a novel method was developed to measure the hydraulic permeability of hydrated collagen gels as a function of gel mass loss. Experimentally measured permeability values of the lamella ranged from 4.3 × 10−15 to 1.2 × 10−14 m2 which were 100 to 1000-fold less than those of the hydrated collagen layer. These experimental data were in close agreement with permeability values estimated by the Happel model. Scanning electron and confocal laser scanning microscopy each confirmed the presence of a two-layer structure beyond three minutes of self-compression. Therefore, the formation of a dense lamella characterized by a significantly reduced hydraulic permeability modulates the kinetics of consolidation, as well as the microstructure of fibrillar collagen gels. This provides important implications and functional significance in the processing of multi-layered biomimetic tissue equivalent collagen based scaffolds and drug delivery systems. |
| Starting Page | 2918 |
| Ending Page | 2926 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 1744683X |
| Volume Number | 7 |
| Issue Number | 6 |
| Journal | Soft Matter |
| DOI | 10.1039/c0sm00691b |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Cell membrane Biomimetics Collagen Darcy Confocal microscopy Drug delivery Gravity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Condensed Matter Physics |
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