NDLI: Polymeric capsule-cushioned leukocyte cell membrane vesicles as a biomimetic delivery platform

Content Provider	Royal Society of Chemistry (RSC)
Author	Wu, Zhiguang Lin, Zhihua He, Qiang Lin, Xiankun Gao, Changyong
Copyright Year	2016
Abstract	We report a biomimetic delivery of microsized capsule-cushioned leukocyte membrane vesicles (CLMVs) through the conversion of freshly reassembled leukocyte membrane vesicles (LMVs), including membrane lipids and membrane-bound proteins onto the surface of layer-by-layer assembled polymeric multilayer microcapsules. The leukocyte membrane coating was verified by using electron microscopy, a quartz crystal microbalance, dynamic light scattering, and confocal laser scanning microscopy. The resulting CLMVs have the ability to effectively evade clearance by the immune system and thus prolong the circulation time in mice. Moreover, we also show that the right-side-out leukocyte membrane coating can distinctly improve the accumulation of capsules in tumor sites through the molecular recognition of membrane-bound proteins of CLMVs with those of tumor cells in vitro and in vivo. The natural cell membrane camouflaged polymeric multilayer capsules with the immunosuppressive and tumor-recognition functionalities of natural leukocytes provide a new biomimetic delivery platform for disease therapy.
Starting Page	3548
Ending Page	3554
Page Count	7
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	8
Issue Number	6
Journal	Nanoscale
DOI	10.1039/c5nr08407e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Electron microscope Biomimetics Dynamic light scattering Cell membrane Confocal microscopy Base pair White blood cell Microbalance Immune system
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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