NDLI: Hydrogel based on an alginate–Ca<sup>2+</sup>/chondroitin sulfate matrix as a potential colon-specific drug delivery system

Content Provider	Royal Society of Chemistry (RSC)
Author	Lopes, Laís C. Silva, Mateus B. Fajardo, André R. Piai, Juliana F. Muniz, Edvani C. Rubira, Adley F.
Copyright Year	2012
Abstract	This work reports on the formation and characterization of a novel hydrogel based on the polysaccharide alginate physically crosslinked by calcium ions (Ca2+) in the presence of chondroitin sulfate (CS). Swelling data and morphological analysis showed that the alginate–Ca2+/CS hydrogel has a clear pH-dependent behavior. Compression tests revealed a gradual decrease in the elastic moduli (E) as the pH of hydrogel-immersed solution is raised but a pronounced decrease for the samples swelled at pH 8 was observed. This fact was attributed to a complete disruption of the polymer network. On the other hand, the hydrogel matrix remains stable when immersed in acidic media. In vitro drug release studies were performed in simulated gastric and intestinal fluids and the collected data showed that the hydrogels formed in this work respond to external stimuli (changes in pH) and, thus, present great potential to be applied in a colon-specific drug delivery system.
Starting Page	11095
Ending Page	11103
Page Count	9
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	2
Issue Number	29
Journal	RSC Advances
DOI	10.1039/c2ra20785k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Elastic modulus Central Cross-Island Highway Calcium Alginic acid Polymer Extracellular matrix Chondroitin sulfate Drug delivery Polysaccharide Gel
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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