NDLI: Dynamic formation of nanostructured particles from vesicles via invertase hydrolysis for on-demand delivery

Content Provider	Royal Society of Chemistry (RSC)
Author	Boyd, Ben J. Ortelli, Francesco Giovanni Sun, Wenjie Mezzenga, Raffaele Sánchez-Ferrer, Antoni Fong, Wye-Khay
Copyright Year	2017
Abstract	The unique multicompartmental nanostructure of lipid-based mesophases can be triggered, on-demand, in order to control the release of encapsulated drugs. In this study, these nanostructured matrices have been designed to respond to a specific enzyme, invertase, an enzyme which catalyses the hydrolysis of sucrose. The effect of two sugar esters upon the phase behaviour of two different lipids which form cubic phases, phytantriol and monolinolein, was investigated. Factors affecting the hydrolysis of the sucrose headgroup are discussed in terms of the molecular structure of the sugar surfactant and also its ability to incorporate into the lipid bilayer. By hydrolysing the incorporated sugar esters, a dynamic change in mesophase nanostructure from vesicles to a cubic phase was observed. This phase change resulted in the triggered release of an encapsulated model drug, fluorescein. This investigation demonstrates, for the first time, that changes on a molecular level by subtly controlling the hydrophilic and hydrophobic features of an amphiphilic additive at the interface by enzymatic hydrolysis can result in a global change in the system and so paves the way towards the design and development of lipid-based matrices which are responsive to specific enzymes for the controlled delivery of pharmaceutically active molecules or functional foods.
Starting Page	4368
Ending Page	4377
Page Count	10
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	7
Issue Number	8
Journal	RSC Advances
DOI	10.1039/c6ra26688f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Sucrose Enzyme Invertase Nanostructure Hydrophobe Surfactant Hydrolysis Phytantriol Fluorescein Lipid bilayer Amphiphile Mesophase Catalysis Hydrophile
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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