NDLI: Thermophilic Enterococcus faecium QU 50 enabled open repeated batch fermentation for l-lactic acid production from mixed sugars without carbon catabolite repression

Content Provider	Royal Society of Chemistry (RSC)
Author	Abdel-Rahman, M. A. Sakai, K. Sonomoto, K. Tashiro, Y. Zendo, T. Tan, J. Numaguchi, M.
Copyright Year	2017
Abstract	Enterococcus faecium QU 50, a novel thermophilic L-lactic acid (LA) producing strain, was used in this study to ferment sugar mixtures into LA. Under the optimal fermentation conditions (50 °C, pH 6.5), strain QU 50 could ferment both mixed glucose/xylose sugars with relaxed CCR and mixed cellobiose/xylose sugars simultaneously without CCR to produce homo L-LA. The activity of enzymes related to xylose metabolism was also investigated. In the cells grown in a medium containing cellobiose/xylose, the activity of xylose isomerase and xylulose kinase, was 3.22 and 1.91 times higher, respectively, as compared to that of cells grown in a glucose/xylose medium. Strain QU 50 produced 70.8 g L−1 of L-LA with a yield of 1.04 g g−1 and a productivity of 2.95 g L−1 h−1 from simulated energy cane hydrolysate in batch fermentation. Immobilisation of strain QU 50 improved the operational stability of open repeated fermentation (three cycles), resulting in 61.1–64.3 g L−1 of L-LA with a yield of 1.01–1.02 g g−1 and a productivity of 3.22–3.82 g L−1 h−1. Thus, an efficient and cost-effective fermentation system was successfully established for L-LA production from sugar mixtures.
Starting Page	24233
Ending Page	24241
Page Count	9
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	7
Issue Number	39
Journal	RSC Advances
DOI	10.1039/c7ra03176a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Sucrose Glucose Fermentation Xylose Enterococcus faecium CCR Thermophile Cellobiose Xylose isomerase Kinase Xylulose Los Angeles Xylose metabolism
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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