NDLI: Ultrasmall polymersomes of poly-α,β-(N-2-hydroxyethyl l-aspartamide)-graft-poly(l-lactic acid) copolymers as a potential drug carrier

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Ultrasmall polymersomes of poly-α,β-(N-2-hydroxyethyl l-aspartamide)-graft-poly(l-lactic acid) copolymers as a potential drug carrier

Content Provider	Royal Society of Chemistry (RSC)
Author	Jang, Kwang-Suk Kwon, Seung-Hae Lee, Hyun Jin
Copyright Year	2016
Abstract	Ultrasmall polymersomes of poly-α,β-(N-2-hydroxyethyl L-aspartamide)-graft-poly(L-lactic acid), 40–45 nm in diameter, were prepared based on a well-defined graft copolymer architecture and well-managed self-assembly process. The ultrasmall polymersomes are a proposed drug delivery platform based on their suitable size, narrow size distribution, uniform morphology, and high thermodynamic stability, which satisfy prerequisites for systemic drug delivery carriers. The functionality and versatility of this system as a potential general drug delivery platform are supported by its biodegradability, favorable modifiable chemical formula, and flexible polymersome size that could be tuned to a nanoscopic range by manipulating the thermodynamic balance of the self-assembly process.
Starting Page	86361
Ending Page	86372
Page Count	12
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	6
Issue Number	89
Journal	RSC Advances
DOI	10.1039/c6ra13675c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Self-assembly Chemical formula Polymersome Drug delivery Copolymer
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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