NDLI: A new ICT and CHEF based visible light excitable fluorescent probe easily detects in vivo Zn<sup>2+</sup>

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A new ICT and CHEF based visible light excitable fluorescent probe easily detects in vivo Zn²⁺

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A new ICT and CHEF based visible light excitable fluorescent probe easily detects in vivo Zn²⁺

Content Provider	Royal Society of Chemistry (RSC)
Author	Das, Sangita Aich, Krishnendu Goswami, Shyamaprosad Mukhopadhyay, Chitrangada Das
Copyright Year	2015
Abstract	A new chelator and ICT donor based visible light excitable Zn2+ sensor was designed and developed by integrating quinoline and 2-hydroxy-3-(hydroxymethyl)-5-methylbenzaldehyde. The probe is sensitive towards Zn2+ in absorbance as well as in fluorescence experiments in 90% aqueous medium. The sensor demonstrates Zn2+-specific emission enhancement due to the ICT and CHEF process with the LOD in the range of 10−8 M. The fluorescence quantum yield of the chemosensor is only 0.02, and it increases almost 11-fold (0.22) after complexation with Zn2+. Interestingly, the introduction of other metal ions causes the fluorescence intensity to remain almost unchanged. Moreover, the ability of the probe (BQ) to sense Zn2+ in living cells has been explored.
Starting Page	31189
Ending Page	31194
Page Count	6
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	5
Issue Number	39
Journal	RSC Advances
DOI	10.1039/c5ra03353e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Chelation Quinoline Fluorescence ICT Quantum tunnelling Chemoreceptor
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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