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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Gwon, Hui-Jeong Jeong, Sung In Shin, Heungsoo Park, Jong-Seok Lim, Youn-Mook Ahn, Sung-Jun Shin, Young Min Lim, Jong-Young |
| Copyright Year | 2015 |
| Abstract | In this work, we present a biomimetic fibrous scaffold containing two biomolecules. A biocompatible poly(L-lactide-co-ε-caprolactone) mesh was fabricated by an electrospinning method, and then acrylic acid was grafted on the mesh to introduce a carboxyl group through γ-ray irradiation. Subsequently, the epidermal growth factor (EGF) and gelatin were coupled to the mesh through the EDC reaction. The modified mesh presents a consistent fibre diameter (874.4 ± 178.5 nm), with carboxyl groups (1.3 mM). EGF (171.7 ng mg−1 mesh) and gelatin (67.2 ± 30.5 μg mg−1 mesh) were successfully coupled on the mesh. The coupled EGF and gelatin promoted the cell viability 1.5-times higher than that from a non-modified mesh. In particular, the EGF on the meshes independently allowed hMSC to present a 3-times greater involucrin expression and enabled improved procollagen secretion, implying trans-differentiation of hMSC to keratinocyte-like cells. Therefore, the co-immobilization strategy of biomolecules using radiation technology may be an alternative tool for tissue engineering applications. |
| Starting Page | 55948 |
| Ending Page | 55956 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 20462069 |
| Volume Number | 5 |
| Issue Number | 69 |
| Journal | RSC Advances |
| DOI | 10.1039/c5ra01626f |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Biomimetics EGF EDC Carboxylic acid Gelatin Tissue engineering Electrospinning Biocompatibility Involucrin Growth factor |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Chemical Engineering |
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