NDLI: Biomimetic 3D hydroxyapatite architectures with interconnected pores based on electrospun biaxially orientated PCL nanofibers

Content Provider	Royal Society of Chemistry (RSC)
Author	Wei, Gang Arras, Matthias M. L. Li, Jingfeng Ouyang, Zhaofei Jandt, Klaus D. Su, Zhiqiang
Copyright Year	2014
Abstract	We report here a facile strategy to fabricate three-dimensional (3D) hydroxyapatite (HA) architectures with well-defined long continuous interconnected pores by using electrospinning and biomimetic mineralization. To this end, a polymeric nanofiber (NF) scaffold with well-defined architecture was fabricated by electrospinning, and bone morphogenetic protein 2 (BMP2) was then adsorbed onto the chemically modified NFs through bio-conjugation. The 3D nanoporous HA architecture was finally fabricated by biomimetic mineralization of the NF–BMP2 hybrid in simulated body fluids and subsequent dissolution of NFs in hexafluoroisopropanol. The formation of NF–BMP2 hybrid was identified by confocal laser scanning microscopy analysis. The crystal structure of HA crystals formed on NFs was examined by X-ray diffraction. The chemical composition and interconnected porous structure of the created 3D HA architectures were measured by X-ray photoelectron spectroscopy, focused ion beam scanning electron microscopy, and transmission electron microscopy, respectively. This bottom-up strategy based on electrospinning and biomimetic mineralization opens up a new way to prepare diverse porous HA-based hybrid materials and shows great potential in drug delivery, gene transfer and tissue engineering.
Starting Page	14833
Ending Page	14839
Page Count	7
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	4
Issue Number	29
Journal	RSC Advances
DOI	10.1039/c3ra46457a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Bone morphogenetic protein 2 Tissue engineering Electrospinning Nanofiber Confocal microscopy Ion Drug delivery Photoemission spectroscopy Scanning electron microscope Three-dimensional space X-ray crystallography Transmission electron microscopy Biomimetics Gene Hydroxylapatite Hexafluoro-2-propanol X-ray photoelectron spectroscopy
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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