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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Govindasamy, Kanimozhi Balupillai, Agilan Gunaseelan, Srithar Shanmugam, Mohana Prasad, N. Rajendra Muthusamy, Ganesan Ramasamy, Karthikeyan |
| Copyright Year | 2016 |
| Abstract | In this study, we evaluated the role of linalool in acute ultraviolet-B (UVB; 280–320 nm) radiation-induced inflammation and chronic UVB-mediated photocarcinogenesis in mouse skin. Acute UVB-irradiation (180 mJ cm−2) causes hyperplasia, edema formation, lipid peroxidation, antioxidant depletion, and overexpression of cyclooxygenase-2 (COX-2) and ornithine decarboxylase (ODC) in mouse skin. Topical or intraperitoneal (i.p.) treatment of linalool prevented acute UVB-induced hyperplasia, edema formation, lipid peroxidation, and antioxidant depletion in mouse skin. Further, linalool treatment prevented UVB-induced overexpression of COX-2 and ODC in mouse skin. In the chronic study, mice were subjected to UVB-exposure thrice weekly for 30 weeks. Chronic UVB-exposure induced tumor incidence and expression of proliferative markers such as NF-κB, TNF-α, IL-6, COX-2, VEGF, TGF-β1, Bcl-2 and mutated p53 in mouse skin. Treatment with linalool before each UVB-exposure significantly prevented the expression of these proliferative markers and subsequently decreased the tumor incidence in mice skin. Histopathological studies confirmed the development of dysplasia and squamous cell carcinoma (SCC) in the chronic UVB-exposed mouse skin; and this was prevented by both topical and i.p. linalool treatment. Therefore, linalool may be considered as a photochemopreventive agent against UVB radiation induced skin carcinogenesis. |
| Starting Page | 851 |
| Ending Page | 860 |
| Page Count | 10 |
| File Format | HTM / HTML PDF |
| ISSN | 1474905X |
| Volume Number | 15 |
| Issue Number | 7 |
| Journal | Photochemical & Photobiological Sciences |
| DOI | 10.1039/c6pp00075d |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | UVB Bcl-2 Carcinoma Hyperplasia Lipid peroxidation Ultraviolet Intraperitoneal injection Carcinogenesis ODC Interleukin 6 NF-κB Cyclooxygenase Tumor necrosis factor alpha Topical medication Vascular endothelial growth factor Edema Dysplasia Inflammation Ornithine decarboxylase Thrice Antioxidant P53 SCC Prostaglandin-endoperoxide synthase 2 Mouse Linalool |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physical and Theoretical Chemistry |
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