NDLI: Haploinsufficiency for odc modifies mouse skin tumor susceptibility.

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Haploinsufficiency for odc modifies mouse skin tumor susceptibility.

Content Provider	Semantic Scholar
Author	Guo, Yongjun Cleveland, John L. O'Brien, Thomas G.
Copyright Year	2005
Abstract	Numerous studies have linked overexpression of ornithine decarboxylase (Odc) gene with enhanced susceptibility to mouse skin tumorigenesis. However, there is little experimental evidence suggesting that modest reductions in Odc expression might reduce tumor susceptibility. To address this issue, here we report the use of the Odc(+/-) haploinsufficiency model, in which one copy of the murine Odc gene has been inactivated by a homologous recombination. Compared with Odc(+/+) mice, Odc(+/-) mice exhibit reduced epidermal ODC enzyme activity and polyamine accumulation following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, following chronic TPA treatment, the characteristic hyperplastic response of the epidermis was diminished in Odc(+/-) mice. Finally, when subjected to a two-stage initiation-promotion protocol, substantially fewer skin papillomas developed in Odc(+/-) mice compared with wild-type littermates. These results support the concept that differences in tissue polyamine levels, resulting from either overexpression or reductions in ODC, are important modifiers of tumor susceptibility.
Starting Page	697
Ending Page	700
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/canres/65/4/1146.full.pdf
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/65/4/1146.full.pdf
PubMed reference number	15734996v1
Volume Number	65
Issue Number	4
Journal	Cancer research
Language	English
Access Restriction	Open
Subject Keyword	Carboxy-Lyases Epidermis Haploinsufficiency Homologous Recombination Hyperplasia Ornithine Decarboxylase Papilloma Skin Carcinogenesis Skin Neoplasms Tetradecanoylphorbol Acetate Tumor Promoters
Content Type	Text
Resource Type	Article

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