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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Farina, Anne Meloni, Marisa Servi, Barbara de |
| Copyright Year | 2010 |
| Abstract | Ultraviolet A (UVA) radiation adversely affects skin health and appearance via multiple molecular pathways. Biologically relevant UVA damage are classified as short-term effects (e.g. formation of reactive oxygen species [ROS], inflammation, photo-oxidation, DNA damage, immunosuppression, photoallergy and cell-mediated contact hypersensitivity) or long-term effects (elastosis, photoageing and photocarcinogenesis). Single and chronic experimental exposure to UVA are limited in humans by ethical concerns, and furthermore it is impossible to quantify long-term endpoints such as photoageing over the life-span of a human volunteer. The aim of the present study was to investigate the biological relevance of the Phenion® FT skin model for use in photobiological studies. Biological responses to acute and repeated UVA exposures were investigated by monitoring the kinetics of gene expression during the post-irradiation period. By using a dynamic approach, we were able to define early and stable markers of UVA-induced effects that could be predictive of UVA damage in vivo. The transcriptomic approach applied to 3D human tissues appears to be an encouraging method for gaining a deeper understanding of the UVA effects on skin and for studying the dermal response with non-invasive techniques. |
| Starting Page | 439 |
| Ending Page | 447 |
| Page Count | 9 |
| File Format | HTM / HTML PDF |
| ISSN | 1474905X |
| Volume Number | 9 |
| Issue Number | 4 |
| Journal | Photochemical & Photobiological Sciences |
| DOI | 10.1039/b9pp00164f |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | UVA Deeper Understanding Reactive oxygen species Immunosuppression Gene DNA Hypersensitivity Inflammation Ultraviolet Photodermatitis Three-dimensional space |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physical and Theoretical Chemistry |
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