NDLI: Biocompatible and pH-sensitive PEG hydrogels with degradable phosphoester and phosphoamide linkers end-capped with amine for controlled drug delivery

Please wait, while we are loading the content...

Thermally cross-linkable hole transporting polymer synthesized by living anionic polymerization for effective electron blocking and reduction of exciton quenching in multilayer polymer light emitting diodes

Trithiocarbonates prepared from iodo-functionalized RITP-polymers

Surface modification of magnetite hybrid particles with carbohydrates and gold nanoparticles via“click” chemistry

Mesogen jacketed liquid crystalline polyacetylene containing triphenylene discogen: synthesis and phase structure

Well-defined cationic polyacrylamides with dot-charges: synthesis via an aqueous living RAFT polymerization, characterization, and intrinsic viscosity

Diblock copolymers consisting of a polymerized ionic liquid and poly(N-isopropylacrylamide). Effects of PNIPAM block length and counter ion on self-assembling and thermal properties

Novel functional degradable block copolymers for the building of reactive micelles

Construction of ‘smart’ surfaces with polymer functionalized silica nanoparticles

Relative reactivity and selectivity of vinyl sulfones and acrylates towards the thiol–Michael addition reaction and polymerization

Exploring shape amphiphiles beyond giant surfactants: molecular design and click synthesis

Steric hindrance effect on thermoresponsive behaviors of pyrrolidone-based polymers

Electron deficient conjugated polymers based on benzotriazole

Biocompatible and pH-sensitive PEG hydrogels with degradable phosphoester and phosphoamide linkers end-capped with amine for controlled drug delivery

Macromolecular engineering via ring-opening polymerization (1): l-lactide/trimethylene carbonate block copolymers as thermoplastic elastomers

Synthesis of amphiphilic copolymers with a dendritic polyethylene core and poly(ethylene oxide) arms and their self-assembled nanostructures

UV-cleavable unimolecular micelles: synthesis and characterization toward photocontrolled drug release carriers

Microporous organic polymers synthesized by self-condensation of aromatic hydroxymethyl monomers

Thiophene spacers impart crystallinity and enhance the efficiency of benzotrithiophene-based conjugated polymers for bulk heterojunction photovoltaics

RAFT polymerization of methacrylates containing a tryptophan moiety: controlled synthesis of biocompatible fluorescent cationic chiral polymers with smart pH-responsiveness

Polymer–trimannoside conjugates via a combination of RAFT and thiol–ene chemistry

Increased open circuit voltage in a fluorinated quinoxaline-based alternating conjugated polymer

Redox initiation of bulk thiol–ene polymerizations

Toward rapid aqueous RAFT polymerization of primary amine functional monomer under visible light irradiation at 25 °C

Reducing polyazomethine to poly(N-phenylbenzylamine) with near infrared electrochromic, fluorescence and photovoltaic properties

Functionalized linear low-density polyethylene by ring-opening metathesis polymerization

pH and reduction dual-responsive nanogel cross-linked by quaternization reaction for enhanced cellular internalization and intracellular drug delivery

Synthesis of hyperbranched polythiophene with a controlled degree of branching via catalyst-transfer Suzuki–Miyaura coupling reaction

Redox-switchable supramolecular polymers for responsive self-healing nanofibers in water

Synthesis of 4-iodotetrahydropyran-containing polymers via TMSI-promoted Prins cyclization

Electrochemically reduced graphene oxide-enhanced electropolymerization of poly-xanthurenic acid for direct, “signal-on” and high sensitive impedimetric sensing of DNA

Polymer electrolyte membranes based on poly(m-phenylene)s with sulfonic acid via long alkyl side chains

Selectively grafting polymer from the interior and/or exterior surfaces of bioreducible and temperature-responsive nanocapsules

Tuning self-assembly of hybrid PLA-P(MA-POSS) block copolymers in solution via stereocomplexation

Morpholine-functionalized polycarbonate hydrogels for heavy metal ion sequestration

Back cover

Polymer Chemistry Vol - 4 Issue - 3

Polymer Chemistry Vol -3

Polymer Chemistry Vol -2

Polymer Chemistry Vol -1

Biocompatible and pH-sensitive PEG hydrogels with degradable phosphoester and phosphoamide linkers end-capped with amine for controlled drug delivery

Content Provider	Royal Society of Chemistry (RSC)
Author	Kim, Il Kang, Dae Hwan Zheng, Sudan Jang, Sung Il Suh, Hongsuk Zhang, Lidong Jeong, Young-Il
Copyright Year	2013
Abstract	A series of biocompatible poly(ethylene glycol) (PEG) hydrogels that are suitable for a variety of biomedical applications have been presented. The cross-linked, water-swellable and multi-amine-functionalized PEG hydrogels (CWMPHs) with degradable phosphoester and phosphoamide linkages in the backbone were successfully produced by the condensation crosslinking reactions between PEG–O–P(O)Cl2 with different functionalities and 3-arm-PEG–NH2 pre-polymers, followed by the chain-terminating amination using propane-1,3-diamine in a one-pot process. The newly invented protocol for the fabrication of PEG hydrogels exhibits promising advantages over prior methods including a short reaction time, mass-production, easy separation, and high yield. The structures of the pre-polymers and CWMPHs were well characterized by FT-IR, 1H NMR, and solid state 31P NMR analyses. The mechanical properties of the CWMPHs measured by a rheometer indicate that both storage modulus (G′) and loss modulus (G′′) increase as the functionality of PEG–O–P(O)Cl2 increases. All the CWMPHs exhibit pH-sensitive water swellability and degradability at room temperature, so that they show a higher water swelling ratio and faster degradation under acidic conditions via an activated cleavage of P–O and P–N bonds. The non-hemolytic property and reasonable biocompatibility of the CWMPHs were proven by in vivo histological assays and in vitro cell viability tests using 293T and HCT-116 cells. We have also demonstrated promising positive results for the use of CWMPHs as a sustained drug delivery system, by mounting an anticancer drug – doxorubicin in vitro, with specifically enhanced release at a low pH 4.0.
Starting Page	1084
Ending Page	1094
Page Count	11
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	4
Issue Number	4
Journal	Polymer Chemistry
DOI	10.1039/c2py20755a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ethylene glycol Diamine Biocompatibility Drug delivery Fourier-transform infrared spectroscopy Nuclear magnetic resonance Rheometer Doxorubicin Propane 293T NCI-60
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Novel pH-sensitive hydrogels for colon-specific drug delivery

Degradable poly(ethylene glycol) (PEG)-based hydrogels for spatiotemporal control of siRNA/nanoparticle delivery

Poly(ethylene glycol)-containing hydrogels in drug delivery (1999)

Synthesis of an amphiphilic PEG-PCL-PSt-PLLA-PAA star quintopolymer and its self-assembly for pH-sensitive drug delivery

Self-assembled micelles of PEG–poly(disulfide carbamate amine) copolymers for intracellular dual-responsive drug delivery

Simulation of Doxorubicin Delivery via Glucosamine(ethylene glycol) Carrier

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

ROS-Generating Poly(Ethylene Glycol)-Conjugated Fe₃O₄ Nanoparticles as Cancer-Targeting Sustained Release Carrier of Doxorubicin.

Enhanced intracellular drug delivery of pH-sensitive doxorubicin /poly(ethylene glycol)- block -poly(4-vinylbenzylphosphonate) nanoparticles in multi- drug resistant human epidermoid KB carcinoma cells

Biocompatible and pH-sensitive PEG hydrogels with degradable phosphoester and phosphoamide linkers end-capped with amine for controlled drug delivery

Similar Documents

Novel pH-sensitive hydrogels for colon-specific drug delivery

Degradable poly(ethylene glycol) (PEG)-based hydrogels for spatiotemporal control of siRNA/nanoparticle delivery

Poly(ethylene glycol)-containing hydrogels in drug delivery (1999)

Synthesis of an amphiphilic PEG-PCL-PSt-PLLA-PAA star quintopolymer and its self-assembly for pH-sensitive drug delivery

Self-assembled micelles of PEG–poly(disulfide carbamate amine) copolymers for intracellular dual-responsive drug delivery

Simulation of Doxorubicin Delivery via Glucosamine(ethylene glycol) Carrier

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

ROS-Generating Poly(Ethylene Glycol)-Conjugated Fe3O4 Nanoparticles as Cancer-Targeting Sustained Release Carrier of Doxorubicin.

Enhanced intracellular drug delivery of pH-sensitive doxorubicin /poly(ethylene glycol)- block -poly(4-vinylbenzylphosphonate) nanoparticles in multi- drug resistant human epidermoid KB carcinoma cells

Biocompatible and pH-sensitive PEG hydrogels with degradable phosphoester and phosphoamide linkers end-capped with amine for controlled drug delivery

ROS-Generating Poly(Ethylene Glycol)-Conjugated Fe₃O₄ Nanoparticles as Cancer-Targeting Sustained Release Carrier of Doxorubicin.