NDLI: UV-cleavable unimolecular micelles: synthesis and characterization toward photocontrolled drug release carriers

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Polymer Chemistry Vol - 4 Issue - 3

Polymer Chemistry Vol -3

Polymer Chemistry Vol -2

Polymer Chemistry Vol -1

UV-cleavable unimolecular micelles: synthesis and characterization toward photocontrolled drug release carriers

Content Provider	Royal Society of Chemistry (RSC)
Author	Chen, Chen Allcock, Harry R. Liu, Xiao Tian, Zhicheng
Copyright Year	2013
Abstract	UV-cleavable star polymers composed of a well-defined 6-arm amphiphilic block copolymer and a UV-cleavable core with photolabile o-nitrobenzyl groups have been synthesized and characterized. The core of the star polymer is a cyclotriphosphazene, which can biodegrade to phosphate and ammonium ion. The resultant unimolecular micelles can be dissociated in a controlled manner by UV irradiation. The inner lipophilic poly(methyl methacrylate) (PMMA) and the outer hydrophilic poly[poly(ethylene glycol) methyl ether methacrylate] (PPEGMA) were grafted by atom transfer radical polymerization (ATRP), leading to the formation of star-PMMA-PPEGMA with different compositions. The effects of various factors, such as molecular weight, solution concentration, solvents (THF, toluene, and water) and monomers (MMA, PEGMA, and 2-(dimethylamino)ethyl methacrylate (DMA)) on the photodegradation rate of the star polymers were studied by gel permeation chromatography (GPC). The micellar behavior of star-PMMA-PPEGMA was unambiguously demonstrated by dynamic light scattering (DLS), fluorescence techniques and transmission electron microscopy (TEM). The formation of nanoparticles (star-AGG) from the aggregation of the two star-PMMA-PPEGMA polymer micelles in aqueous solution was detected by DLS with hydrodynamic radii of 86 and 111 nm. The critical aggregation concentration (CAC) of star-AGG-2 from star-PMMA179-PPEGMA89-2 was 0.0026 g L−1 and 0.022 g L−1 before and after UV-irradiation indicating the reduced stability of the polymer micellar structures after UV-irradiation due to the detachment of the amphiphilic arms from the cyclotriphosphazene core. As a result, spontaneous dissociation of cleaved micelles can be induced by the dilution effect in the human body for stimulus-controlled drug release.
Starting Page	1115
Ending Page	1125
Page Count	11
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	4
Issue Number	4
Journal	Polymer Chemistry
DOI	10.1039/c2py20825c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Atom-transfer radical-polymerization PEGMA Ammonium Hydrodynamic radius Micelle Fluorescence Dissociative Star-shaped polymer THF Dynamic light scattering Phosphate Copolymer Hydrophile Dimethylacetamide MMA Photodegradation Ethylene glycol Ether Toluene Ion Poly(methyl methacrylate) Polymer Para-Methoxy-N-methylamphetamine Gel permeation chromatography Transmission electron microscopy Amphiphile Lipophilicity
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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