NDLI: Functional block copolymer nanoparticles: toward the next generation of delivery vehicles

Content Provider	Royal Society of Chemistry (RSC)
Author	Hawker, Craig J. Connal, Luke A. Lee, Bongjae F. Robb, Maxwell J. Lynd, Nathaniel A.
Copyright Year	2012
Abstract	The self-assembly of functional block copolymers (BCPs) into dispersed nanoparticles is a powerful technique for the preparation of novel delivery vehicles with precise control of morphology and architecture. Well-defined BCPs containing an alkyne-functional, biodegradable polylactide (PLA) block were synthesized and conjugated with azide-functional coumarin dyes via copper catalyzed azide alkyne cycloaddition ‘click’ chemistry. Self-assembled nanoparticles with internal nanophase-separated morphologies could then be accessed by carefully controlling the composition of the BCPs and release of the covalently attached model payload was shown to occur under physiological conditions via the degradation of the PLA scaffold. These results demonstrate the potential of self-assembled nanoparticles as modular delivery vehicles with multiple functionalities, nanostructures, and compartmentalized internal morphology.
Starting Page	1618
Ending Page	1628
Page Count	11
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	3
Issue Number	6
Journal	Polymer Chemistry
DOI	10.1039/c2py20131c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Biodegradation Organic chemistry Self-assembly Cycloaddition PLA Copper Azide Coumarin Alkyne
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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