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Back cover

Polymer Chemistry Vol -2

Polymer Chemistry Vol -1

High relaxivity MRI imaging reagents from bimodal star polymers

Content Provider	Royal Society of Chemistry (RSC)
Author	Radford, Kelly Adkins, Chinessa T. Hamilton, Sharon K. Udoji, Felicia Mayrsohn, Brian Dobish, Julia N. Gore, John C. Harth, Eva Yankeelov, Thomas E. Brown, Clifford S.
Copyright Year	2012
Abstract	Star polymer architectures were developed as multimodal imaging systems as fluorescence and magnetic resonance imaging (MRI) agents. Acrylate star polymers in hydrodynamic diameters of 10 ± 2 nm comprising fluorene derivatives as core units were modified with dopamine derivatives in adjustable quantities to chelate lanthanides such as Gd3+ and Eu3+. Ionic relaxivity values of 84 mM−1s−1 in an applied magnetic field of 0.5T at 37 °C confirmed the rapid water exchange of the highly hydrated star polymer. The utility is extended by the consecutive modification with allyl groups to perform thiol-ene reactions to conjugate thiol modified targeting units such as (cRGD) and dendritic molecular transporter as cell penetrating units. Cell uptake experiments in NIH 3T3 cells showed a rapid uptake of the star polymer independently of the presence of molecular transporter unit as it was detected through both the blue fluorescence of the fluorine core and the red fluorescence of the complexed Eu3+ to the linear polymer arms. In vivo mouse models confirmed the star polymer imaging reagent altered the image contrast significantly. In this work, we have adapted macromolecules as imaging agents for fluorescence microscopy and magnetic resonance imaging in conjunction with intracellular delivery and targeting.
Starting Page	390
Ending Page	398
Page Count	9
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	3
Issue Number	2
Journal	Polymer Chemistry
DOI	10.1039/c1py00474c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Fluorene Thiol Dopamine Allyl group Fluorine Fluorescence Polymer Fluorescence microscope National Institutes of Health NIH Reagent Star-shaped polymer Magnetic resonance imaging Mouse Acrylate Ionic order Magnetic field
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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