NDLI: Biodegradable core crosslinked star polymer nanoparticles as <sup>19</sup>F MRI contrast agents for selective imaging

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Polymer Chemistry Vol - 5 Issue - 4

Polymer Chemistry Vol - 5 Issue - 3

Polymer Chemistry Vol -4

Polymer Chemistry Vol -3

Polymer Chemistry Vol -2

Polymer Chemistry Vol -1

Biodegradable core crosslinked star polymer nanoparticles as ¹⁹F MRI contrast agents for selective imaging

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Kewei Puttick, Simon Thurecht, Kristofer J. Whittaker, Andrew K. Peng, Hui
Copyright Year	2014
Abstract	With the aim of developing stimuli-responsive imaging agents, we report here the synthesis of core crosslinked star (CCS) polymers and their evaluation as pH-sensitive 19F magnetic resonance imaging (19F MRI) contrast agents. Block copolymers consisting of poly(ethylene glycol)methyl ether methacrylate (PPEGMA) as the first block and a copolymer of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and 2,2,2-trifluoroethyl methacrylate (TFEMA) as the second block were synthesised using RAFT polymerisation. The polymerisation kinetics were studied in detail. The block copolymers were then used as arm precursors for the arm-first synthesis of CCS polymers through RAFT dispersion polymerisation. The synthetic conditions were investigated and optimised. CCS polymers with a degradable core were also synthesised and evaluated as 19F MRI contrast agents. The degradation of the core was confirmed by treatment with various reducing agents. The particle size, 19F NMR signal and relaxation times as well as 19F MRI imaging performance of the CCS polymers were studied at a range of value of solution pH. Significant enhancement of the image intensity was observed when the pH was decreased from 8 to 5, indicating that the CCS nanoparticles could be used as 19F MRI contrast agents for the detection of the acidic environment within tumour tissue.
Starting Page	1760
Ending Page	1771
Page Count	12
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	5
Issue Number	5
Journal	Polymer Chemistry
DOI	10.1039/c3py01311a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ethylene glycol CCS Magnetic resonance imaging Ether Dispersion relation Copolymer Nuclear magnetic resonance Fluorine-19 nuclear magnetic resonance
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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