NDLI: Modular design for the controlled production of polymeric nanotubes from polymer/peptide conjugates

Content Provider	Royal Society of Chemistry (RSC)
Author	Perrier, Sébastien Chapman, Robert Jolliffe, Katrina A.
Copyright Year	2011
Abstract	We have established a new strategy to produce functional organic nanotubes of controlled structure from cyclic peptide/polymer conjugates. The structure guiding cyclic peptide motif was coupled to the polymeric chains viacopper-catalyzed azide–alkyne click reaction, to yield very well-defined conjugates. The resulting conjugates were then self-assembled into nanotubes in solution. We were able to control to some extent the length of the nanotubes, by modifying the length of the polymer chain as well as by mixing conjugates of different molecular weights together. In a similar fashion we were able to prepare functional tubes from a range of polymers including poly(butyl acrylate), poly(dimethyl amino ethyl acrylate), poly(acrylic acid), poly(styrene) and poly(hydroxyl ethyl acrylate), as well as tubes with mixed functionality, by self-assembling a mixture of conjugates of differing polymer functionality. This modular approach is a powerful technique to generate a large number of nanotubes of varying size and functionality, in a controlled and rapid process. We believe this new approach will permit the design of a wide range of functional organic nanotubes of controlled structure, in a simple and efficient process.
Starting Page	1956
Ending Page	1963
Page Count	8
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	2
Issue Number	9
Journal	Polymer Chemistry
DOI	10.1039/c1py00202c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cyclic peptide Hydroxy group Carboxylic acid Acrylate Styrene Polymer Butyl acrylate
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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