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Contents list

Cu(0)-mediated living radical polymerization: recent highlights and applications; a perspective

A heptacyclic acceptor unit developed for D–A copolymers used in polymer solar cells

Modulating the cellular uptake of platinum drugs with glycopolymers

Atom transfer radical polymerization by solvent-stabilized (Me₃TACN)FeX₂: a practical access to reusable iron(ii) catalysts

New unsaturated copolyesters based on 2,5-furandicarboxylic acid and their crosslinked derivatives

Multifunctional hyperbranched polymers for CT/¹⁹F MRI bimodal molecular imaging

Synthesis of platinum-containing poly(phenyleneethynylene)s having various chromophores: aggregation and optical properties

Cobalt(iii) and copper(ii) hydrides at the crossroad of catalysed chain transfer and catalysed radical termination: a DFT study

Redox-controlled upper critical solution temperature behaviour of a nitroxide containing polymer in alcohol–water mixtures

Toughened aromatic poly-(decylene terephthalate) copolyesters with two renewable eugenol-based components via a random copolymerization method

Three is company: dual intramolecular hydrogen-bond enabled carboxylic acid active in ring-opening polymerization

Synthesis and AIE properties of PEG–PLA–PMPC based triblock amphiphilic biodegradable polymers

One for all: cobalt-containing polymethacrylates for magnetic ceramics, block copolymerization, unexpected electrochemistry, and stimuli-responsiveness

Smart block copolymers of PVP and an alkylated PVP derivative: synthesis, characterization, thermoresponsive behaviour and self-assembly

Efficient red emission from poly(vinyl butyral) films doped with a novel europium complex based on a terpyridyl ancillary ligand: synthesis, structural elucidation by Sparkle/RM1 calculation, and photophysical properties

Organic–inorganic polyimides with double decker silsesquioxane in the main chains

Synthesis and in-depth characterization of reactive, uniform, crosslinked microparticles based on free radical copolymerization of 4-vinylbenzyl azide

An ultra-narrow bandgap derived from thienoisoindigo polymers: structural influence on reducing the bandgap and self-organization

Ultrathin free-standing polymer membranes with chemically responsive luminescence via consecutive photopolymerizations

Synthesis of amphiphilic block-type macromolecular brushes with cleavable pendant chains and fabrication of micelle-templated polymer nanocapsules

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Modulating the cellular uptake of platinum drugs with glycopolymers

Content Provider	Royal Society of Chemistry (RSC)
Author	Callari, Manuela Lu, Hongxu Dag, Aydan Stenzel, Martina H.
Copyright Year	2016
Abstract	The therapeutic potency of platinum-based anticancer drugs can be substantially improved through the use of polymeric nanocarrier systems to target cancer cells efficiently. We synthesized a series of glyco-block copolymers with three different sugars able to self-assemble into nanoparticles when conjugated with 1,2-diamino-cyclopentane platinum(II) (DACP-Pt). The polymers are based on (2-(D-glucosyloxy)ethyl methacrylate (glucose; GlcMA), 2-(D-galactosyloxy)ethyl methacrylate (galactose; GalMA), 1-O-methacryloyl-β-D-fructopyranose (fructose; FrucMA1), and 3-O-methacryloyl-β-D-fructopyranose (fructose; FrucMA3)). They are all readily taken up intracellularly by the breast cancer cell lines MCF-7 and MDA-MB-231 and the ovarian cancer cell line A2780. All cell lines expressed a high preference for the fructose coated nanoparticles. The nanocarriers were themselves nontoxic, but exhibited high cytotoxicity and increased efficacy when conjugated with the DACP-Pt drug.
Starting Page	1031
Ending Page	1036
Page Count	6
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	7
Issue Number	5
Journal	Polymer Chemistry
DOI	10.1039/c5py01579k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MCF-7 Cytotoxicity Breast cancer List of breast cancer cell lines Glucose Galactose List of places in The Chronicles of Narnia Fructose Cancer Ovarian cancer
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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Modulating the cellular uptake of platinum drugs with glycopolymers

Uptake and Cytotoxicity Characterization of Radioiodine in MCF-7 and SKBR3 Breast Cancer Cell Lines

Uptake and Cytotoxicity Characterization of Radioiodine in MCF-7 and SKBR3 Breast Cancer Cell Lines

Investigation of glucose catabolism in hypoxic Mcf 7 breast cancer culture.

Evaluation of synthesized platinum nanoparticles on the MCF-7 and HepG-2 cancer cell lines

pH-sensitive polycarbonate micelles for enhanced intracellular release of anticancer drugs: a strategy to circumvent multidrug resistance

Metformin interferes with glucose cellular uptake by both estrogen and progesterone receptor-positive (MCF-7) and triple-negative (MDA-MB-231) breast cancer cell lines: PS156.

Water-soluble BODIPY-conjugated glycopolymers as fluorescent probes for live cell imaging

Biosynthesized silver nanoparticles and miR34a mimics mediated activation of death receptor in MCF-7 human breast cancer cell lines

Modulating the cellular uptake of platinum drugs with glycopolymers

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Modulating the cellular uptake of platinum drugs with glycopolymers

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Modulating the cellular uptake of platinum drugs with glycopolymers