NDLI: Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution

Content Provider	Royal Society of Chemistry (RSC)
Author	Jia, Bing Shi, Jiyun Gan, Zhihua Zhang, Jiajing Dong, Chengyan Wang, Fan Yu, Qingsong
Copyright Year	2014
Abstract	Well-defined water-soluble block copolymers poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide-co-N-methacryloylglycylglycine) (PEG-b-P(HPMA-co-MAGG)) with different compositions and narrow polydispersity were synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization. The in vivo blood clearance and biodistribution of copolymers with different compositions were studied in normal BALB/c mice. The results showed that the electronegative copolymers were rapidly eliminated from blood and tended to accumulate in the liver and spleen. However, the copolymers with neutral or a small amount of negative charges showed a prolonged circulation time and low non-specific organ uptake. Combined with the quantitative analysis of in vitro hepatocyte uptake, we conclude that this was due to the balance between (i) the electrostatic repulsion between the copolymer and the cell membrane and (ii) the tendency of macrophage-like cells to capture the negative charged copolymers. This work also revealed the significant roles of the PEG chain length, negative charge and molecular weight for the copolymers as anticancer drug carriers with prolonged circulation time and optimal biodistribution.
Starting Page	5617
Ending Page	5627
Page Count	11
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	5
Issue Number	19
Journal	Polymer Chemistry
DOI	10.1039/c4py00681j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Dispersity Spleen Ethylene glycol Chain transfer Hepatocyte Cell membrane Liver Polymerization Electronegativity Copolymer
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Poly(N-(2-hydroxypropyl) methacrylamide)-based nanotherapeutics

Salt-induced reentrant hydrogel of poly(ethylene glycol)–poly(lactide-co-glycolide) block copolymers

Synthesis and Self-Assembly of Well-Defined Poly(amino acid) End-Capped Poly(ethylene glycol) and Poly(2-methyl-2-oxazoline)

Poly[N-(2-hydroxypropyl)methacrylamide] nanogels by RAFT polymerization in inverse emulsion

A general synthetic strategy to prepare poly(ethylene glycol)-based multifunctional copolymers

Synthesis of polystyrene-b-poly(ethylene glycol) block copolymers by radical exchange reactions of terminal RAFT agents

Dual transitions of toothbrush-like double hydrophilic block copolymers

Synthesis and characterization of ABA-type block copolymer of poly(trimethylene carbonate) with poly(ethylene glycol): Bioerodible copolymer

Solubility of naphthalene in aqueous solutions of poly(ethylene glycol)–poly(propylene glycol)–poly(ethylene glycol) triblock copolymers and (2-hydroxypropyl)cyclodextrins

Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution

Similar Documents

Poly(N-(2-hydroxypropyl) methacrylamide)-based nanotherapeutics

Salt-induced reentrant hydrogel of poly(ethylene glycol)–poly(lactide-co-glycolide) block copolymers

Synthesis and Self-Assembly of Well-Defined Poly(amino acid) End-Capped Poly(ethylene glycol) and Poly(2-methyl-2-oxazoline)

Poly[N-(2-hydroxypropyl)methacrylamide] nanogels by RAFT polymerization in inverse emulsion

A general synthetic strategy to prepare poly(ethylene glycol)-based multifunctional copolymers

Synthesis of polystyrene-b-poly(ethylene glycol) block copolymers by radical exchange reactions of terminal RAFT agents

Dual transitions of toothbrush-like double hydrophilic block copolymers

Synthesis and characterization of ABA-type block copolymer of poly(trimethylene carbonate) with poly(ethylene glycol): Bioerodible copolymer

Solubility of naphthalene in aqueous solutions of poly(ethylene glycol)–poly(propylene glycol)–poly(ethylene glycol) triblock copolymers and (2-hydroxypropyl)cyclodextrins

Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution