NDLI: Fibril-shaped aggregates of doxorubicin with poly-l-lysine and its derivative

Content Provider	Royal Society of Chemistry (RSC)
Author	Liang, Fuxin Qu, Xiaozhong Zhu, Feiyan Wang, Qian Li, Zhibo Yang, Saina Liang, Yongri Li, Jiaoli Zhu, Lijun Yang, Zhenzhong
Copyright Year	2014
Abstract	Complex formation between polymers and organic molecules is an interesting topic in polymer physics. Compared to the influence of small molecules on polymer assembly, there are fewer examples demonstrating the effect of polymers on the supramolecular structures formed by organic molecules. In this paper, we first prove that doxorubicin (DOX), a common anti-tumour drug, assembles into fibril-like aggregates in phosphate buffer (pH 7.4) and then show that the assembly of DOX was influenced by the complexation with an amphiphilic poly (amino acid) derivative, i.e. cholate-grafted poly-L-lysine (PLL-CA). With PLL-CA, the DOX fibrils converted to helix structured nano-spindles, whilst the presence of PLL led to minor change on the morphology of PLL/DOX complex compared to the DOX aggregates, which is attributed to the amplitude of intermolecular interactions. As a DNA intercalating agent, the aggregation of DOX on its biofunctionality was also investigated, showing that the formation of fibril assemblies was unfavourable for the cellular internalization of DOX and caused lower cytotoxicity to DOX resistance MCF-7 cells, whereas the polymer/DOX complexes gained an improved cell uptake on the MCF-7/ADR cell line due to an enhanced electrostatic interaction between the complexes and the cell membrane.
Starting Page	5700
Ending Page	5706
Page Count	7
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	5
Issue Number	19
Journal	Polymer Chemistry
DOI	10.1039/c4py00686k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cell membrane MCF-7 Polymer Cytotoxicity Intercalation (biochemistry) Doxorubicin Physics Carboxylic acid Phosphate DNA Amphiphile Fibril
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dual responsive micelles based on poly[(R)-3-hydroxybutyrate] and poly(2-(di-methylamino)ethyl methacrylate) for effective doxorubicin delivery

Controlled biomimetic silica formation using star-shaped poly(l-lysine)

pH-sensitive polycarbonate micelles for enhanced intracellular release of anticancer drugs: a strategy to circumvent multidrug resistance

Dextran-based redox-responsive doxorubicin prodrug micelles for overcoming multidrug resistance

A multifunctional self-dissociative polyethyleneimine derivative coating polymer for enhancing the gene transfection efficiency of DNA/polyethyleneimine polyplexes in vitro and in vivo

Photocleavable glycopolymer aggregates

Reduction-sensitive core-cross-linked mPEG–poly(ester-carbonate) micelles for glutathione-triggered intracellular drug release

A novel cyclodextrin-containing pH-responsive star polymer for nanostructure fabrication and drug delivery

Preparation of pH and redox dual-sensitive core crosslinked micelles for overcoming drug resistance of DOX

Fibril-shaped aggregates of doxorubicin with poly-l-lysine and its derivative

Similar Documents

Dual responsive micelles based on poly[(R)-3-hydroxybutyrate] and poly(2-(di-methylamino)ethyl methacrylate) for effective doxorubicin delivery

Controlled biomimetic silica formation using star-shaped poly(l-lysine)

pH-sensitive polycarbonate micelles for enhanced intracellular release of anticancer drugs: a strategy to circumvent multidrug resistance

Dextran-based redox-responsive doxorubicin prodrug micelles for overcoming multidrug resistance

A multifunctional self-dissociative polyethyleneimine derivative coating polymer for enhancing the gene transfection efficiency of DNA/polyethyleneimine polyplexes in vitro and in vivo

Photocleavable glycopolymer aggregates

Reduction-sensitive core-cross-linked mPEG–poly(ester-carbonate) micelles for glutathione-triggered intracellular drug release

A novel cyclodextrin-containing pH-responsive star polymer for nanostructure fabrication and drug delivery

Preparation of pH and redox dual-sensitive core crosslinked micelles for overcoming drug resistance of DOX

Fibril-shaped aggregates of doxorubicin with poly-l-lysine and its derivative