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Back matter

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Organic & Biomolecular Chemistry Vol -5

Organic & Biomolecular Chemistry Vol -4

Organic & Biomolecular Chemistry Vol -3

Organic & Biomolecular Chemistry Vol -2

Conformationally rigid proteomimetics: a case study in designing antimicrobial aryl oligomers

Content Provider	Royal Society of Chemistry (RSC)
Author	Gabriel, Gregory J. Tew, Gregory N.
Copyright Year	2008
Abstract	The promise of proteomics to provide a vast library of protein structural data is exciting to scientists desiring an unprecedented understanding of the relationship between protein structure and function. This powerful knowledge will provide insight into the design rules for proteomimetics which are oligomers and polymers that can be more stable and inexpensive to produce than natural proteins, but still emulate the main biological function of the natural molecule. This Emerging Area article is intended to stimulate discussion on innovative strategies to design the next generation of proteomimetics. Specifically we will examine the design evolution of facially amphiphilic aryl oligomers, compounds that act as synthetic mimics of antimicrobial peptides (SMAMPs) and are known to interact with lipid bilayers. An increasingly important goal in the field of antimicrobial polymers is to develop strategies to rationally design membrane-binding SMAMPs, that are highly cell-selective, from any preferred backbone and molecular weight. It is expected that lessons learned from studying these oligomers can be applied to other systems where mimics are desired to interact with extended surfaces and where it would be most productive to consider mimicking the protein of interest with a large molecule. Obvious examples include disrupting protein–protein interactions or binding long tracts of DNA to control gene expression.
Starting Page	417
Ending Page	423
Page Count	7
File Format	HTM / HTML PDF
ISSN	14770520
Volume Number	6
Issue Number	3
Journal	Organic & Biomolecular Chemistry
DOI	10.1039/b714490n
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Gene DNA Proteomics Antimicrobial peptides Gene regulatory network Amphiphile Nerve tract Library Aryl Protein structure Protein Lipid
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Physical and Theoretical Chemistry

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