NDLI: Efficient photothermal therapy of brain cancer through porphyrin functionalized graphene oxide

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Jilong Wang, Shiren Wei, Junhua Qiu, Jingjing Su, Siheng Martínez-Zaguilán, Raul
Copyright Year	2015
Abstract	Current clinical treatments including surgical resection, radiation therapy and chemotherapy for brain cancer result in high mortality due to the complex structure of the brain aggressiveness of brain cancer. Recently, non-invasive photothermal therapy (PTT) using near infrared laser irradiation has been developed as an alternative emerging therapy for brain cancer. In this paper, a biocompatible porphyrin functionalized graphene oxide (PGO) with high absorbance at 808 nm is synthesized as a photothermal platform for brain cancer therapy. Graphite oxide is exfoliated and conjugated with porphyrin through π–π interactions. This PGO is two times more stable than reduced graphene oxide (rGO) in aqueous solution. Most importantly, the efficiency of the photo-thermal conversion of PGO is increased by 89% and 33% compared to graphene oxide and rGO under 808 nm laser irradiation, causing ablation of a large number of brain cancer cells in vitro. This PGO platform containing active functional groups allows specific targeting in PTT without harming healthy cells and tissues.
Starting Page	5743
Ending Page	5749
Page Count	7
File Format	HTM / HTML PDF
ISSN	11440546
Volume Number	39
Issue Number	7
Journal	New Journal of Chemistry
DOI	10.1039/c5nj00122f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	PTT Chemotherapy Infrared Porphyrin Graphene Laser Partial thromboplastin time Biocompatibility Radiation therapy Glioblastoma multiforme Ablation
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Catalysis

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