NDLI: Expeditious synthesis of functionalized tricyclic 4-spiro pyrano[2,3-c]pyrazoles in aqueous medium using dodecylbenzenesulphonic acid as a Brønsted acid

Content Provider	Royal Society of Chemistry (RSC)
Author	Mukherjee, Prasun Das, Asish R. Paul, Sanjay
Copyright Year	2015
Abstract	An efficient, three-component, one-pot synthesis of highly functionalized tricyclic 4-spiro pyrano[2,3-c]pyrazoles incorporating medicinally privileged heterocyclic moieties has been developed, which also involves the tandem Knoevenagel/Michael addition reaction followed by dehydrative cyclization of pyrazolone derivatives, cyclic 1,3-diketones and cyclic ketones, catalyzed by dodecylbenzenesulphonic acid (DBSA) as a Brønsted acid–surfactant-combined catalyst in aqueous medium. The catalyst is found to be highly competent in accelerating this reaction that results in a considerable short reaction time, alleviating the need for high thermal energy. Wide substrate scope, high to excellent product yield, operational simplicity, absence of any hazardous organic solvent, mild reaction conditions, a simple work up procedure and easily available starting materials are the salient features of this protocol.
Starting Page	9480
Ending Page	9486
Page Count	7
File Format	HTM / HTML PDF
ISSN	11440546
Volume Number	39
Issue Number	12
Journal	New Journal of Chemistry
DOI	10.1039/c5nj01728a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	One-pot synthesis DBSA Carboxylic acid Addition reaction Pyrazolone Solvent Heterocyclic compound Thermal energy
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Catalysis

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Expeditious synthesis of functionalized tricyclic 4-spiro pyrano[2,3-c]pyrazoles in aqueous medium using dodecylbenzenesulphonic acid as a Brønsted acid–surfactant-combined catalyst