NDLI: Enhanced cytotoxicity by a benzothiazole-containing cisplatin derivative in breast cancer cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Zhu, Jin Sun, Yu Luo, Yanghui Zhang, Xiangyang Sun, Baiwang You, Chaoqun Yu, Jia
Copyright Year	2017
Abstract	In recent years, the concept of nanoparticles being used as an intelligent drug carrier has gained great attention. In this paper, the formulation of a liposome delivery system loaded with a novel benzothiazole-containing cisplatin derivative (CJM-Pt) was carried out. The particle size distributions were determined using dynamic light scattering, and the prepared liposomes showed a suitable size of around 98 nm. Stability studies showed that the CJM-Pt loaded liposomes were stable at 4 °C for more than four weeks. Investigation of triggered release indicated that the release performance of the prepared liposomes was controllable and the releasing effect was remarkable under low pH (<pH 6.8) and high temperature (>42 °C). To test the suitability of the chosen formulation, CJM-Pt loaded liposomes were investigated against several tumor cell lines: MGC-803, SGC-7901, MCF-7 and MDA-MB-231. Furthermore, the cell cycle arrest was examined. The CJM-Pt loaded liposomes have the potential to be applied in drug delivery systems (DDS) for breast cancer therapy.
Starting Page	773
Ending Page	785
Page Count	13
File Format	HTM / HTML PDF
ISSN	11440546
Volume Number	41
Issue Number	2
Journal	New Journal of Chemistry
DOI	10.1039/c6nj02753a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Dynamic light scattering MCF-7 Cell cycle Liposome PH List of breast cancer cell lines Drug delivery Breast cancer Cisplatin
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Chemistry Catalysis

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