NDLI: Quantifying signal changes in nano-wire based biosensors

Content Provider	Royal Society of Chemistry (RSC)
Author	Iversen, Lars Rogers, David M. Nygård, Jesper Martinez, Karen L. Sørensen, Brian S. Vico, Luca De Brandbyge, Mads Jensen, Jan H. Sørensen, Martin H.
Copyright Year	2011
Abstract	In this work, we present a computational methodology for predicting the change in signal (conductance sensitivity) of a nano-BIOFET sensor (a sensor based on a biomolecule binding another biomolecule attached to a nano-wire field effect transistor) upon binding its target molecule. The methodology is a combination of the screening model of surface charge sensors in liquids developed by Brandbyge and co-workers [Sørensen et al., Appl. Phys. Lett., 2007, 91, 102105], with the PROPKA method for predicting the pH-dependent charge of proteins and protein-ligand complexes, developed by Jensen and co-workers [Liet al., Proteins: Struct., Funct., Bioinf., 2005, 61, 704–721, Bas et al., Proteins: Struct., Funct., Bioinf., 2008, 73, 765–783]. The predicted change in conductance sensitivity based on this methodology is compared to previously published data on nano-BIOFET sensors obtained by other groups. In addition, the conductance sensitivity dependence from various parameters is explored for a standard wire, representative of a typical experimental setup. In general, the experimental data can be reproduced with sufficient accuracy to help interpret them. The method has the potential for even more quantitative predictions when key experimental parameters (such as the charge carrier density of the nano-wire or receptor density on the device surface) can be determined (and reported) more accurately.
Starting Page	706
Ending Page	717
Page Count	12
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	3
Issue Number	2
Journal	Nanoscale
DOI	10.1039/c0nr00442a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Jensen Biomolecule Appl Bas Dependent and independent variables Cell surface receptor Tamburica Charge carrier Brandbyge Transistor LIET
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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