NDLI: Facile synthesis of an up-conversion luminescent and mesoporous Gd2O3 : Er3+@nSiO2@mSiO2 nanocomposite as a drug carrier

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Nanoscale Vol -2

Nanoscale Vol -1

Facile synthesis of an up-conversion luminescent and mesoporous Gd₂O₃ : Er³⁺@nSiO₂@mSiO₂ nanocomposite as a drug carrier

Content Provider	Royal Society of Chemistry (RSC)
Author	Kang, Xiaojiao Hou, Zhiyao Lin, Jun Ma, Ping'an Li, Chunxia Xu, Zhenhe Yang, Dongmei
Copyright Year	2011
Abstract	In this paper, we report the facile synthesis of a bifunctional inorganic nanocomposite which is composed of core-shell structured mesoporous silica coated with up-conversion Gd2O3 : Er3+ particles. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2adsorption/desorption, and photoluminescence (PL) spectra were used to characterize the samples. The results indicate that the nanocomposite with general 50 nm shell thickness and 300 nm core size shows typical ordered mesoporous characteristics (2.3 nm) and has spherical morphology with smooth surface and narrow size distribution. The bifunctional system shows unique green up-conversion emission under 980 nm NIR laser excitation even after loading with drug molecules. In addition, biocompatibility tests on L929 fibroblast cells using an MTT assay reveals low cytotoxicity of the system. Drug release tests suggest that the nanocomposite has a controlled drug release property with ibuprofen (IBU) as the model drug. Interestingly, the up-conversion emission intensity of the bifunctional carrier increases with the released amount of model drug, thus allowing the release process to be monitored and tracked by the change of up-conversion luminescence intensity. This composite can potentially act as a functional drug carrier system.
Starting Page	661
Ending Page	667
Page Count	7
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	3
Issue Number	2
Journal	Nanoscale
DOI	10.1039/c0nr00695e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Beer measurement Photoluminescence Luminescence Cytotoxicity Scanning electron microscope MTT assay X-ray crystallography Mesoporous material Transmission electron microscopy Mesoporous silica Laser Ibuprofen Biocompatibility Nanocomposite Emission intensity Fibroblast Drug prohibition law
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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