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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Cai, Hanxu Zhang, Xingdong Bian, Shaoquan Fan, Yujiang Sun, Yong Xu, Zhiyi Zhou, Ling Liang, Jie Sui, Junhui Cui, Yani |
| Copyright Year | 2017 |
| Abstract | pH-Sensitive pullulan-doxorubicin conjugates encapsulating sorafenib (P-Dox/S) nanoparticles were developed as a synergistic combinatorial delivery system against murine breast carcinoma. The nanoparticles can encapsulate Dox and sorafenib with ultra-high loading capacity (65.34 wt%) through chemical conjugation and physical loading, whereas can remain stable under physiological conditions and gradually release Dox and sorafenib with the decreasing pH. These conjugates can be effectively internalized and clearly suppress 4T1 cell growth in vitro. Furthermore, research data of in vivo animal models revealed that the synergistic combinatorial P-Dox/S nanoparticles heavily accumulated in solid tumor tissue sites to maximize therapeutic efficacy; they also significantly inhibited solid tumor growth, even remarkably reduced solid tumor volume in comparison to the initial volume, and obviously diminished adverse effects. The anti-tumor therapeutic effect obviously outperformed the delivery of combinational chemotherapy of free drugs or single drug-loaded P-Dox nanoparticles at the same concentration. These promising results indicate the high-efficiency synergistic chemotherapeutic effects of these nanoparticles. Combinational chemotherapy using P-Dox/S nanoparticles has important potential in the clinical treatment of malignancy for overcoming drug resistance and heterogeneity. |
| Starting Page | 2755 |
| Ending Page | 2767 |
| Page Count | 13 |
| File Format | HTM / HTML PDF |
| ISSN | 20403364 |
| Volume Number | 9 |
| Issue Number | 8 |
| Journal | Nanoscale |
| DOI | 10.1039/c6nr09639e |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Chemotherapy Carcinoma Sorafenib PH Dox Combinatorics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology |
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