NDLI: Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo

Content Provider	Royal Society of Chemistry (RSC)
Author	Cheng, Qiang Huo, Shuaidong Zhang, Yanan Zhang, Chunqiu Liu, Juan Ma, Xiaowei Liang, Xing-Jie Zhao, Jing Wei, Tuo Duan, Xianglin
Copyright Year	2016
Abstract	Prostate cancer is highly prevalent and has become the second leading cause of cancer-related death in men. Its treatment remains a challenge in the clinic, particularly in patients who have advanced to “castration-resistant prostate cancer” (CRPC). Thus, more effective therapeutic strategies are required. Quercetin (QCT) is a natural flavonoid compound that has attracted increasing interest due to its anticancer activity. However, the clinical application of quercetin is largely hampered by its poor water solubility and low bioavailability. The objective of this study was to evaluate the therapeutic potential of novel QCT-loaded nanomicelles (M-QCTs) assembled from DSPE-PEG2000 for prostate cancer treatment. Our results indicated that QCT was efficiently encapsulated into micelles up to 1 mg mL−1, which corresponds to a 450-fold increase of its water solubility. In vitro studies showed that the half-maximal inhibitory concentration (IC50) value (20.2 μM) of M-QCTs was much lower than free QCT (>200 μM). Thus, M-QCTs were considerably more effective than free QCT in proliferation inhibition and apoptosis induction of human androgen-independent PC-3 cells. Furthermore, M-QCTs showed superior antitumor efficacy and the tumor proliferation rate reduced by 52.03% compared to the control group in the PC-3 xenograft mouse model, possibly due to increased accumulation of M-QCTs at the tumor site by the enhanced permeability and retention (EPR) effect. Collectively, our studies demonstrated that M-QCTs significantly increase drug accumulation at the tumor site and exhibit superior anticancer activity in prostate cancer. Thus, our nanomicelle-based drug delivery system constitutes a promising and effective therapeutic strategy for clinical treatment.
Starting Page	5126
Ending Page	5138
Page Count	13
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	8
Issue Number	9
Journal	Nanoscale
DOI	10.1039/c5nr08966b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	PC3 Mouse Cell membrane EPR Xenotransplantation Quercetin IC50 Drug delivery Bioavailability Prostate cancer Flavonoid Apoptosis
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cy: phellinus linteus extract sensitizes advanced prostate cancer cells to apoptosis in athymic nude mice. Plos one 5(3):e9885.

Intravenous delivery of enzalutamide based on high drug loading multifunctional graphene oxide nanoparticles for castration-resistant prostate cancer therapy

Mechanism of Notch1‑saRNA‑1480 reversing androgen sensitivity in human metastatic castration‑resistant prostate cancer.

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation

Flavonoid Calycopterin Induces Apoptosis in Human Prostate Cancer Cells In-vitro.

Efficient In Vitro TRAIL-Gene Delivery in Drug-Resistant A2780/DDP Ovarian Cancer Cell Line via Magnetofection

Targeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo

Enhanced Tumor Targeting and Radiotherapy by Quercetin Loaded Biomimetic Nanoparticles

Fabrication of paclitaxel hybrid nanomicelles to treat resistant breast cancer via oral administration.

Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo

Similar Documents

Cy: phellinus linteus extract sensitizes advanced prostate cancer cells to apoptosis in athymic nude mice. Plos one 5(3):e9885.

Intravenous delivery of enzalutamide based on high drug loading multifunctional graphene oxide nanoparticles for castration-resistant prostate cancer therapy

Mechanism of Notch1‑saRNA‑1480 reversing androgen sensitivity in human metastatic castration‑resistant prostate cancer.

Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation

Flavonoid Calycopterin Induces Apoptosis in Human Prostate Cancer Cells In-vitro.

Efficient In Vitro TRAIL-Gene Delivery in Drug-Resistant A2780/DDP Ovarian Cancer Cell Line via Magnetofection

Targeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo

Enhanced Tumor Targeting and Radiotherapy by Quercetin Loaded Biomimetic Nanoparticles

Fabrication of paclitaxel hybrid nanomicelles to treat resistant breast cancer via oral administration.

Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo