NDLI: Scientific and industrial challenges of developing nanoparticle-based theranostics and multiple-modality contrast agents for clinical application

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Extracting local surface charges and charge regulation behavior from atomic force microscopy measurements at heterogeneous solid-electrolyte interfaces

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Thin-walled SnO₂ nanotubes functionalized with Pt and Au catalysts via the protein templating route and their selective detection of acetone and hydrogen sulfide molecules

Silica–gold bilayer-based transfer of focused ion beam-fabricated nanostructures

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High-quality elliptical iron glycolate nanosheets: selective synthesis and chemical conversion into Fe_xO_y nanorings, porous nanosheets, and nanochains with enhanced visible-light photocatalytic activity

Efficient subwavelength focusing of light with a long focal depth

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Understanding the electric field control of the electronic and optical properties of strongly-coupled multi-layered quantum dot molecules

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Scientific and industrial challenges of developing nanoparticle-based theranostics and multiple-modality contrast agents for clinical application

Content Provider	Royal Society of Chemistry (RSC)
Author	Corot, Claire Wáng, Yì Xiáng J. Idée, Jean-Marc
Copyright Year	2015
Abstract	Designing of theranostics and dual or multi-modality contrast agents are currently two of the hottest topics in biotechnology and biomaterials science. However, for single entity theranostics, a right ratio of their diagnostic component and their therapeutic component may not always be realized in a composite suitable for clinical application. For dual/multiple modality molecular imaging agents, after in vivo administration, there is an optimal time window for imaging, when an agent is imaged by one modality, the pharmacokinetics of this agent may not allow imaging by another modality. Due to reticuloendothelial system clearance, efficient in vivo delivery of nanoparticles to the lesion site is sometimes difficult. The toxicity of these entities also remains poorly understood. While the medical need of theranostics is admitted, the business model remains to be established. There is an urgent need for a global and internationally harmonized re-evaluation of the approval and marketing processes of theranostics. However, a reasonable expectation exists that, in the near future, the current obstacles will be removed, thus allowing the wide use of these very promising agents.
Starting Page	16146
Ending Page	16150
Page Count	5
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	7
Issue Number	39
Journal	Nanoscale
DOI	10.1039/c5nr03887a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Biotechnology Biomaterial Lesion Pharmacokinetics Mononuclear phagocyte system
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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