NDLI: In vivo translocation and toxicity of multi-walled carbon nanotubes are regulated by microRNAs

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Dayong Li, Yiping Wu, Qiuli Zhao, Yunli Jia, Ruhan Nouara, Abdelli
Copyright Year	2014
Abstract	We employed an in vivo Caenorhabditis elegans assay system to perform SOLiD sequencing analysis to identify the possible microRNA (miRNA) targets of multi-walled carbon nanotubes (MWCNTs). Bioinformatics analysis on targeted genes for the identified dysregulated miRNAs in MWCNT exposed nematodes demonstrates their involvement in many aspects of biological processes. We used loss-of-function mutants for the identified dysregulated miRNAs to perform toxicity assessment by evaluating functions of primary and secondary targeted organs, and found the miRNA mutants with susceptible or resistant property towards MWCNT toxicity. Both the physiological state of the intestine and defecation behavior were involved in the control of the susceptible or resistant property occurrence for specific miRNA mutants towards MWCNT toxicity. This work provides the molecular basis at the miRNA level for future chemical design to reduce the nanotoxicity of MWCNTs and further elucidation of the related toxicological mechanism.
Starting Page	4275
Ending Page	4284
Page Count	10
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	6
Issue Number	8
Journal	Nanoscale
DOI	10.1039/c3nr06784j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Carbon nanotube Staurogyne elegans MicroRNA Gastrointestinal tract Bioinformatics ABI Solid Sequencing Defecation
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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