NDLI: NIR photoregulated chemo- and photodynamic cancer therapy based on conjugated polyelectrolyte–drug conjugate encapsulated upconversion nanoparticles

Content Provider	Royal Society of Chemistry (RSC)
Author	Liu, Bin Xing, Bengang Min, Yuanzeng Hu, Qinglian Yuan, Youyong
Copyright Year	2014
Abstract	The design of nanoplatforms with target recognition and near-infrared (NIR) laser photoregulated chemo- and photodynamic therapy is highly desirable but remains challenging. In this work, we have developed such a system by taking advantage of a conjugated polyelectrolyte (CPE)–drug conjugate and upconversion nanoparticles (UCNPs). The poly(ethylene glycol) (PEG) grafted CPE not only serves as a polymer matrix for UCNP encapsulation, but also as a fluorescent imaging agent, a photosensitizer as well as a carrier for chemotherapeutic drug doxorubicin (DOX) through a UV-cleavable ortho-nitrobenzyl (NB) linker. Upon 980 nm laser irradiation, the UCNPs emit UV and visible light. The up-converted UV light is utilized for controlled drug release through the photocleavage of the ortho-nitrobenzyl linker, while the up-converted visible light is used to initiate the polymer photosensitizer to produce reactive oxygen species (ROS) for photodynamic therapy. The NIR photo-regulated UCNP@CPE–DOX showed high efficiency of ROS generation and controlled drug release in cancer cells upon single laser irradiation. In addition, the combination therapy showed enhanced inhibition of U87-MG cell growth as compared to sole treatments. As two light sources with different wavelengths are always needed for traditional photodynamic therapy and photoregulated drug release, the adoption of UCNPs as an NIR light switch is highly beneficial to combined chemo- and photodynamic therapy with enhanced therapeutic effects.
Starting Page	11259
Ending Page	11272
Page Count	14
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	6
Issue Number	19
Journal	Nanoscale
DOI	10.1039/c4nr03302g
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ethylene glycol Reactive oxygen species Photodynamic therapy Polymer Doxorubicin MG Cars Polyelectrolyte Laser CPE Extracellular matrix Photosensitizer Drug prohibition law Cancer
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Conjugated polyelectrolyte–cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking

Photosensitizer-doped conjugated polymer nanoparticles for simultaneous two-photon imaging and two-photon photodynamic therapy in living cells

Silica-based nanoparticles for photodynamic therapy applications

Actively targeting d-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactic acid) nanoparticles as vesicles for chemo-photodynamic combination therapy of doxorubicin-resistant breast cancer

NaYbF₄ nanoparticles as near infrared light excited inorganic photosensitizers for deep penetration in photodynamic therapy

ROS-Generating Poly(Ethylene Glycol)-Conjugated Fe₃O₄ Nanoparticles as Cancer-Targeting Sustained Release Carrier of Doxorubicin.

Amphiphilic copolymer coated upconversion nanoparticles for near-infrared light-triggered dual anticancer treatment

Redox- and light-responsive alginate nanoparticles as effective drug carriers for combinational anticancer therapy

Combined chemo- and photo-thermal therapy delivered by multifunctional theranostic gold nanorod-loaded microcapsules

NIR photoregulated chemo- and photodynamic cancer therapy based on conjugated polyelectrolyte–drug conjugate encapsulated upconversion nanoparticles

Similar Documents

Conjugated polyelectrolyte–cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking

Photosensitizer-doped conjugated polymer nanoparticles for simultaneous two-photon imaging and two-photon photodynamic therapy in living cells

Silica-based nanoparticles for photodynamic therapy applications

Actively targeting d-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactic acid) nanoparticles as vesicles for chemo-photodynamic combination therapy of doxorubicin-resistant breast cancer

NaYbF4 nanoparticles as near infrared light excited inorganic photosensitizers for deep penetration in photodynamic therapy

ROS-Generating Poly(Ethylene Glycol)-Conjugated Fe3O4 Nanoparticles as Cancer-Targeting Sustained Release Carrier of Doxorubicin.

Amphiphilic copolymer coated upconversion nanoparticles for near-infrared light-triggered dual anticancer treatment

Redox- and light-responsive alginate nanoparticles as effective drug carriers for combinational anticancer therapy

Combined chemo- and photo-thermal therapy delivered by multifunctional theranostic gold nanorod-loaded microcapsules

NIR photoregulated chemo- and photodynamic cancer therapy based on conjugated polyelectrolyte–drug conjugate encapsulated upconversion nanoparticles

NaYbF₄ nanoparticles as near infrared light excited inorganic photosensitizers for deep penetration in photodynamic therapy

ROS-Generating Poly(Ethylene Glycol)-Conjugated Fe₃O₄ Nanoparticles as Cancer-Targeting Sustained Release Carrier of Doxorubicin.