NDLI: Amphiphilic copolymer coated upconversion nanoparticles for near-infrared light-triggered dual anticancer treatment

Content Provider	Royal Society of Chemistry (RSC)
Author	Chen, Dongyun Liu, Zhuang Sha, Wenwei Lu, Jianmei Yang, Shun Xu, Qingfeng Li, Najun
Copyright Year	2014
Abstract	The light-triggered controlled release of anticancer drugs accompanied with NIR-responsive photodynamic therapy was prepared via a self-assembly process. Firstly, Mn2+-doped upconversion nanoparticles (UCNPs) were coated with a mesoporous silica shell and modified with photosensitizer (Chlorin e6) and long alkyl chains. And then the NIR light-responsive amphiphilic copolymer containing 9,10-dialkoxyanthracene groups was synthesized and then coated as the outermost layer. Upon irradiation with a 980 nm laser, the CCUCNPs@PM would absorb and then convert the NIR light to higher-energy visible red light (660 nm) via the UCNPs-based core, which could excite Chlorin e6 (Ce-6) to produce singlet oxygen (1O2). Then the 1O2-sensitive dialkoxyanthracene group in the amphiphilic copolymer would be degraded and detach from the surface of the CCUCNPs@PM, followed by the controlled release of the pre-loaded drugs and the photodynamic therapy for cancer cells caused by the excess 1O2. In vitro and in vivo experiments also demonstrated that the drug-loaded CCUCNPs@PM possessed better therapeutic efficacy compared with vacant ones. Therefore, the NIR light-controlled chemotherapy and photodynamic therapy could be realized simultaneously by CCUCNPs@PM.
Starting Page	14903
Ending Page	14910
Page Count	8
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	6
Issue Number	24
Journal	Nanoscale
DOI	10.1039/c4nr05305b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Photodynamic therapy Chlorin Self-assembly Chemotherapy Singlet oxygen Alkyl NIR Mesoporous silica Laser Amphiphile Copolymer Photosensitizer Cancer
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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