NDLI: Ultraporous interweaving electrospun microfibers from PCL–PEO binary blends and their inflammatory responses

Content Provider	Royal Society of Chemistry (RSC)
Author	Li, Yan-Fang Rubert, Marina Chen, Menglin Besenbacher, Flemming Aslan, Hüsnü Dong, Mingdong Yu, Ying Howard, Kenneth A.
Copyright Year	2014
Abstract	Production of one dimensional nanomaterials with secondary morphology exhibiting unique functions is challenging. Here we report for the first time that a nanoscale immiscible polymer blend solution electrojet can assemble into ultraporous interweaving microfibers. This intriguingly novel morphology originated from a blend of polycaprolactone (PCL) and polyethylene oxide (PEO) in a DCM–DMF mixed solution when the ratio between each component reached a threshold and when the electrospinning parameters were delicately controlled. The morphology, crystallinity, surface chemistry and wettabilities were characterized to understand the mechanism of formation. The interplay of the two semi-crystalline polymers and the pair of solvents/non-solvents with the electrospinning processing parameters was found to be critical for the formation of the unique structure. Furthermore, the interesting combination of biocompatible, biodegradable PCL with protein-resistant PEO motivated us to assess its inflammation responses on the RAW 264.7 macrophage cell line. All fibers were found to be biocompatible with low inflammation potential upon incubation, while compared with pure PCL nanofibers; the unique interweaving microfibers induced a slightly higher inflammatory reaction.
Starting Page	3392
Ending Page	3402
Page Count	11
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	6
Issue Number	6
Journal	Nanoscale
DOI	10.1039/c3nr06197c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Biodegradation Electrospinning Nanomaterials Polymer Inflammation Polyethylene glycol Interplay Entertainment Surface science Biocompatibility Raw image format Electrojet Polycaprolactone Macrophage
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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