NDLI: Slowing and controlling the translocation of DNA in a solid-state nanopore

Content Provider	Royal Society of Chemistry (RSC)
Author	Stolovitzky, Gustavo Martyna, Glenn Luan, Binquan
Copyright Year	2012
Abstract	DNA sequencing methods based on nanopores could potentially represent a low-cost and high-throughput pathway to practical genomics, by replacing current sequencing methods based on synthesis that are limited in speed and cost. The success of nanopore sequencing techniques requires the solution to two fundamental problems: (1) sensing each nucleotide of a DNA strand, in sequence, as it passes through a nanopore; (2) delivering each nucleotide in a DNA strand, in turn, to a sensing site within the nanopore in a controlled manner. It has been demonstrated that a DNA nucleotide can be sensed using electric signals, such as ionic current changes caused by nucleotide blockage at a constriction region in a protein pore or a tunneling current through the nucleotide-bridged gap of two nanoelectrodes built near a solid-state nanopore. However, it is not yet clear how each nucleotide in a DNA strand can be delivered in turn to a sensing site and held there for a sufficient time to ensure high fidelity sensing. This latter problem has been addressed by modifying macroscopic properties, such as a solvent viscosity, ion concentration or temperature. Also, the DNA transistor, a solid state nanopore dressed with a series of metal–dielectric layers has been proposed as a solution. Molecular dynamics simulations provide the means to study and to understand DNA transport in nanopores microscopically. In this article, we review computational studies on how to slow down and control the DNA translocation through a solid-state nanopore
Starting Page	1068
Ending Page	1077
Page Count	10
File Format	HTM / HTML PDF
ISSN	20403364
Volume Number	4
Issue Number	4
Journal	Nanoscale
DOI	10.1039/c1nr11201e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Viscosity Nanopore sequencing Genomics DNA Nucleotide Molecular dynamics Ion Transistor Nanopore Solvent Protein DNA sequencing
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology

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