NDLI: A general map of iron metabolism and tissue-specific subnetworks

Please wait, while we are loading the content...

Differential cold–adaptation among protein components of the thioredoxin system in the psychrophilic eubacterium Pseudoalteromonas haloplanktis TAC 125

Targeted lipidomic analysis of oxysterols in the embryonic central nervous system

Folding of single-stranded DNA quadruplexes containing an autonomously stable mini-hairpin loop

Real-time apta-PCR for 20 000-fold improvement in detection limit

Back matter

Back cover

Molecular BioSystems Vol - 5 Issue - 4

Molecular BioSystems Vol - 5 Issue - 3

Molecular BioSystems Vol - 5 Issue - 2

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

A general map of iron metabolism and tissue-specific subnetworks

Content Provider	Royal Society of Chemistry (RSC)
Author	Hower, Valerie Torti, Suzy V. Mendes, Pedro Torti, Frank M. Laubenbacher, Reinhard Shulaev, Vladmir Akman, Steven
Copyright Year	2009
Abstract	Iron is required for survival of mammalian cells. Recently, understanding of iron metabolism and trafficking has increased dramatically, revealing a complex, interacting network largely unknown just a few years ago. This provides an excellent model for systems biology development and analysis. The first step in such an analysis is the construction of a structural network of iron metabolism, which we present here. This network was created using CellDesigner version 3.5.2 and includes reactions occurring in mammalian cells of numerous tissue types. The iron metabolic network contains 151 chemical species and 107 reactions and transport steps. Starting from this general model, we construct iron networks for specific tissues and cells that are fundamental to maintaining body iron homeostasis. We include subnetworks for cells of the intestine and liver, tissues important in iron uptake and storage, respectively, as well as the reticulocyte and macrophage, key cells in iron utilization and recycling. The addition of kinetic information to our structural network will permit the simulation of iron metabolism in different tissues as well as in health and disease.
Starting Page	422
Ending Page	443
Page Count	22
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	5
Issue Number	5
Journal	Molecular BioSystems
DOI	10.1039/b816714c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Metabolic network Systems biology Human iron metabolism Liver Homeostasis Gastrointestinal tract Reticulocyte Macrophage
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A General Map of Iron Metabolism and Tissue-specific Subnetworks

The reconstruction and analysis of tissue specific human metabolic networks

Regulation of systemic metabolism by tissue-resident immune cell circuits.

Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors

Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network

Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism.

Tissue-resident stem cell activity: a view from the adult Drosophila gastrointestinal tract

Macrophage polarization in pathology

Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis

A general map of iron metabolism and tissue-specific subnetworks

Similar Documents

A General Map of Iron Metabolism and Tissue-specific Subnetworks

The reconstruction and analysis of tissue specific human metabolic networks

Regulation of systemic metabolism by tissue-resident immune cell circuits.

Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors

Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network

Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism.

Tissue-resident stem cell activity: a view from the adult Drosophila gastrointestinal tract

Macrophage polarization in pathology

Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis

A general map of iron metabolism and tissue-specific subnetworks