NDLI: The reconstruction and analysis of tissue specific human metabolic networks

Please wait, while we are loading the content...

Hydrophilic interaction and reversed-phase ultraperformance liquid chromatography TOF-MS for serum metabonomic analysis of myocardial infarction in rats and its applications

Specific in situ discrimination of amyloid fibrils versusα-helical fibres by the fluorophore NIAD-4

Probabilistic RNA partitioning generates transient increases in the normalized variance of RNA numbers in synchronized populations of Escherichia coli

Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphoribosyltransferase

More effective antimicrobial mastoparan derivatives, generated by 3D-QSAR-Almond and computational mutagenesis

¹H NMR-based metabonomics study on serum of renal interstitial fibrosis rats induced by unilateral ureteral obstruction

Effects of intermittent media replacement on the gene expression of differentiating neural progenitor cells

A synthetic heparan sulfate oligosaccharide library reveals the novel enzymatic action of d-glucosaminyl 3-O-sulfotransferase-3a

Analyzing the metabolic stress response of recombinant Escherichia coli cultures expressing human interferon-beta in high cell density fed batch cultures using time course transcriptomic data

iLoc-Hum: using the accumulation-label scale to predict subcellular locations of human proteins with both single and multiple sites

Analysis of the Fragile X mental retardation protein isoforms 1, 2 and 3 interactions with the G-quadruplex forming semaphorin 3F mRNA

Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-kappa B activity in leukemic cells

The reconstruction and analysis of tissue specific human metabolic networks

Back cover

Molecular BioSystems Vol -7

Molecular BioSystems Vol -6

Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

The reconstruction and analysis of tissue specific human metabolic networks

Content Provider	Royal Society of Chemistry (RSC)
Author	Goryanin, Igor Zhao, Xue-Ming Hao, Tong Ma, Hong-Wu
Copyright Year	2012
Abstract	Human tissues have distinct biological functions. Many proteins/enzymes are known to be expressed only in specific tissues and therefore the metabolic networks in various tissues are different. Though high quality global human metabolic networks and metabolic networks for certain tissues such as liver have already been studied, a systematic study of tissue specific metabolic networks for all main tissues is still missing. In this work, we reconstruct the tissue specific metabolic networks for 15 main tissues in human based on the previously reconstructed Edinburgh Human Metabolic Network (EHMN). The tissue information is firstly obtained for enzymes from Human Protein Reference Database (HPRD) and UniprotKB databases and transfers to reactions through the enzyme–reaction relationships in EHMN. As our knowledge of tissue distribution of proteins is still very limited, we replenish the tissue information of the metabolic network based on network connectivity analysis and thorough examination of the literature. Finally, about 80% of proteins and reactions in EHMN are determined to be in at least one of the 15 tissues. To validate the quality of the tissue specific network, the brain specific metabolic network is taken as an example for functional module analysis and the results reveal that the function of the brain metabolic network is closely related with its function as the centre of the human nervous system. The tissue specific human metabolic networks are available at http://csb.inf.ed.ac.uk/humandb/.
Starting Page	663
Ending Page	670
Page Count	8
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	8
Issue Number	2
Journal	Molecular BioSystems
DOI	10.1039/c1mb05369h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Human Protein Reference Database UniProt Metabolic network EHMN Liver Nervous system Edinburgh Human Metabolic Network
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

REPORT The Edinburgh human metabolic network reconstruction and its functional analysis

The Edinburgh human metabolic network reconstruction and its functional analysis

A general map of iron metabolism and tissue-specific subnetworks

The Universal Protein Resource (UniProt) (2004)

Human Protein Reference Database and Human Proteinpedia as resources for phosphoproteome analysis

Tools enabling the elucidation of molecular pathways active in human disease: Application to Hepatitis C virus infection

SWIFTCORE: a tool for the context-specific reconstruction of genome-scale metabolic networks

Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE

Compartmentalization of the Edinburgh Human Metabolic Network

The reconstruction and analysis of tissue specific human metabolic networks

Similar Documents

REPORT The Edinburgh human metabolic network reconstruction and its functional analysis

The Edinburgh human metabolic network reconstruction and its functional analysis

A general map of iron metabolism and tissue-specific subnetworks

The Universal Protein Resource (UniProt) (2004)

Human Protein Reference Database and Human Proteinpedia as resources for phosphoproteome analysis

Tools enabling the elucidation of molecular pathways active in human disease: Application to Hepatitis C virus infection

SWIFTCORE: a tool for the context-specific reconstruction of genome-scale metabolic networks

Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE

Compartmentalization of the Edinburgh Human Metabolic Network

The reconstruction and analysis of tissue specific human metabolic networks