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Front cover

Contents

Hot off the PressHot off the RSC Press ( Molecular BioSystems Vol - 3 Issue - 2 )

Thermodynamics of protein denatured states

Regulating gene expression with light-activated oligonucleotides

System properties of ErbB receptor signaling for the understanding of cancer progression

Single-molecule studies of complex systems: the replisome

DNA and RNA induced enantioselectivity in chemical synthesis

Aldehyde metabolism in the cardiovascular system

A cancer protein microarray platform using antibody fragments and its clinical applications

Back cover

Molecular BioSystems Vol -2

Regulating gene expression with light-activated oligonucleotides

Content Provider	Royal Society of Chemistry (RSC)
Author	Tang, XinJing Dmochowski, Ivan J.
Copyright Year	2007
Abstract	Since the development of light-responsive amino acids, the activity of numerous biomolecules has been photomodulated in biochemical, biophysical, and cellular assays. Biological problems of even greater complexity motivate the development of quantitative methods for controlling gene activity with high spatial and temporal resolution, using light as an external trigger. Photoresponsive DNA and RNA oligonucleotides would optimally serve this purpose, but have proven difficult to expand from proofs-of-concept to in vivo experiments. Until recently, the development of this technology was limited by the synthesis of oligonucleotides whose function could be significantly modulated with near-UV light. New synthetic protocols and strategies for both up- and down-regulating gene activity finally make it possible to address biological considerations. In the near future, we can expect photoresponsive DNA and RNA molecules that are relatively non-toxic, nuclease-resistant, and maintain their specificity and activity in vivo. Quantitative, laser-initiated methods for controlling DNA and RNA function will illuminate new areas in cell and developmental biology.
Starting Page	100
Ending Page	110
Page Count	11
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	3
Issue Number	2
Journal	Molecular BioSystems
DOI	10.1039/b614349k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Gene RNA DNA Molecular biology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Taking control of gene expression with light-activated oligonucleotides

Inactivating Gene Expression with Antisense Modified Oligonucleotides.

Regulating gene expression in human leukemia cells (2007).

Regulating gene expression in human leukemia cells (2007)

Regulating gene expression in human leukemia cells using light-activated oligodeoxynucleotides

Regulating gene expression with light-activated oligonucleotides.

Genetic spell-checking: gene editing using single-stranded DNA oligonucleotides

The exhibition of polyethylene imine/DNA coated with oligonucleotides for gene delivery

LADL: Light-activated dynamic looping for endogenous gene expression control

Regulating gene expression with light-activated oligonucleotides

Similar Documents

Taking control of gene expression with light-activated oligonucleotides

Inactivating Gene Expression with Antisense Modified Oligonucleotides.

Regulating gene expression in human leukemia cells (2007).

Regulating gene expression in human leukemia cells (2007)

Regulating gene expression in human leukemia cells using light-activated oligodeoxynucleotides

Regulating gene expression with light-activated oligonucleotides.

Genetic spell-checking: gene editing using single-stranded DNA oligonucleotides

The exhibition of polyethylene imine/DNA coated with oligonucleotides for gene delivery

LADL: Light-activated dynamic looping for endogenous gene expression control

Regulating gene expression with light-activated oligonucleotides