NDLI: Endothelial cell's biomechanical properties are regulated by invasive cancer cells

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Hypothesis: butyrate is not an HDAC inhibitor, but a product inhibitor of deacetylation

Proteoglycan sequence

Genome-scale genetic manipulation methods for exploring bacterial molecular biology

Endothelial cell's biomechanical properties are regulated by invasive cancer cells

Synthetic antibodies as tools to probe RNA-binding protein function

Evaluating the physiological state of maize (Zea mays L.) plants by direct-injection electrospray mass spectrometry (DIESI-MS)

Identification of novel components of NAD-utilizing metabolic pathways and prediction of their biochemical functions

Mapping the genome of Plasmodium falciparum on the drug-like chemical space reveals novel anti-malarial targets and potential drug leads

Revisiting the homology modeling of G-protein coupled receptors: β₁-adrenoceptor as an example

The lipid composition of isolated cytoplasmic lipid droplets from a human cancer cell line, BE(2)M17

Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates

Positive regulatory dynamics by a small noncoding RNA: speeding up responses under temperature stress

Naïve Bayes QSDR classification based on spiral-graph Shannon entropies for protein biomarkers in human colon cancer

Systematic determinations of SUMOylation activation intermediates and dynamics by a sensitive and quantitative FRET assay

Proteomic analysis of a drosophila IBMPFD model reveals potential pathogenic mechanisms

Fabrication of nanostructures through molecular self-assembly of small amphiphilic glyco-dehydropeptides

Insertion of T4-lysozyme (T4L) can be a useful tool for studying olfactory-related GPCRs

Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment

E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe–Phe bonds

Metabolomic analysis of the plasma of patients with high-altitude pulmonary edema (HAPE) using ¹H NMR

Integrated investigation of lipidome and related signaling pathways uncovers molecular mechanisms of tetramethylpyrazine and butylidenephthalide protecting endothelial cells under oxidative stress

Backbone conformational preferences of an intrinsically disordered protein in solution

Proteolysis of beta-galactosidase following SigmaB activation in Bacillus subtilis

Engineering a large protein by combined rational and random approaches: stabilizing the Clostridium thermocellum cellobiose phosphorylase

Rewiring and dosing of systems modules as a design approach for synthetic mammalian signaling networks

An orthogonal comparison of the proteome of human embryonic stem cells with that of human induced pluripotent stem cells of different genetic background

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Molecular BioSystems Vol - 8 Issue - 5

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Molecular BioSystems Vol - 8 Issue - 3

Molecular BioSystems Vol - 8 Issue - 2

Molecular BioSystems Vol -7

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Molecular BioSystems Vol -5

Molecular BioSystems Vol -4

Molecular BioSystems Vol -3

Molecular BioSystems Vol -2

Endothelial cell's biomechanical properties are regulated by invasive cancer cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Mierke, Claudia T.
Copyright Year	2012
Abstract	Most cancer-related deaths are caused by the ability of cancer cells to metastasize. This process includes the dissemination of cancer cells from the primary tumor side and their migration to targeted organ sites. During the migration of cancer cells through the connective tissue microenvironment, which consists of endothelial cells and extracellular matrix components, biomechanical properties are crucial for the efficiency and speed of cancer cell invasion and subsequently, metastases formation. Biomechanics can enable cancer cells to migrate through tissue, transmigrate through basement membranes as well as endothelial monolayers and form metastases in targeted organs. The current focus of cancer research still lies on the investigation of cancer cell's biochemical and molecular capabilities such as molecular genetics and gene signaling, but these approaches ignore the mechanical nature of the invasion process of cancer cells. Moreover, even the role of the endothelium during the transmigration and invasion of cells is not clear, it has been seen as a passive barrier, but this could not explain all novel findings. This review discusses how cancer cells alter the structural, biochemical and mechanical properties of the endothelium to regulate their own invasiveness through extracellular matrices and hence, through the tissue microenvironment. Finally, this review sheds light on the mechanical properties of cancer cells and the interacting endothelium and points out the importance of the mechanical properties as a critical determinant for the efficiency of cancer cell invasion and the overall progression of cancer. In conclusion, the regulation of the endothelial cell's biomechanical properties by cancer cells is a critical determinant of cancer cell invasiveness and may affect the future development of new cancer treatments.
Starting Page	1639
Ending Page	1649
Page Count	11
File Format	HTM / HTML PDF
ISSN	1742206X
Volume Number	8
Issue Number	6
Journal	Molecular BioSystems
DOI	10.1039/c2mb25024a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Biomechanics Connective tissue Molecular genetics Gene Determinant Extracellular matrix Metastasis Cancer Endothelium
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Fibulin-5 Is Up-regulated by Hypoxia in Endothelial Cells through a Hypoxia-inducible Factor-1 (HIF-1α)-dependent Mechanism

Extracellular Matrix (ECM) Proteoglycans Produced by Cultured Bovine Corneal Endothelial Cells

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Mitogenic Properties of Tumor Spheroids for Endothelial Cells Are Related to Their Age

Endothelial cell's biomechanical properties are regulated by invasive cancer cells

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Extracellular Matrix (ECM) Proteoglycans Produced by Cultured Bovine Corneal Endothelial Cells

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