NDLI: Serum metabolomics reveals that arsenic exposure disrupted lipid and amino acid metabolism in rats: a step forward in understanding chronic arsenic toxicity

Please wait, while we are loading the content...

Metallomics and NMR-based metabolomics of Chlorella sp. reveal the synergistic role of copper and cadmium in multi-metal toxicity and oxidative stress

Antiangiogenic ruthenium(ii) benzimidazole complexes, structure-based activation of distinct signaling pathways

Proteomic analysis of the copper resistance of Streptococcus pneumoniae

Classification models based on the level of metals in hair and nails of laryngeal cancer patients: diagnosis support or rather speculation?

Dissolved cerium contributes to uptake of Ce in the presence of differently sized CeO₂-nanoparticles by three crop plants

Metal ion mediated transition from random coil to β-sheet and aggregation of Bri2-23, a natural inhibitor of Aβ aggregation

Isotopic analysis of Cu in blood serum by multi-collector ICP-mass spectrometry: a new approach for the diagnosis and prognosis of liver cirrhosis?

Effects of non-toxic zinc exposure on human epidermal keratinocytes

Extravasation of Pt-based chemotherapeutics – bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS)

Size- and surface chemistry-dependent pharmacokinetics and tumor accumulation of engineered gold nanoparticles after intravenous administration

A new page on the road book of inorganic mercury in fish body – tissue distribution and elimination following waterborne exposure and post-exposure periods

Small angle X-ray scattering analysis of Cu²⁺-induced oligomers of the Alzheimer's amyloid β peptide

Serum metabolomics reveals that arsenic exposure disrupted lipid and amino acid metabolism in rats: a step forward in understanding chronic arsenic toxicity

The biological effect of the nitroimidazole derivative of a polypyridyl ruthenium complex on cancer and endothelial cells

A set of robust fluorescent peptide probes for quantification of Cu(ii) binding affinities in the micromolar to femtomolar range

Back cover

Metallomics Vol - 7 Issue - 2

Serum metabolomics reveals that arsenic exposure disrupted lipid and amino acid metabolism in rats: a step forward in understanding chronic arsenic toxicity

Content Provider	Royal Society of Chemistry (RSC)
Author	Mu, Xiaoli Tian, Meiping Liu, Liangpo Huang, Qingyu Alamdar, Ambreen Zhang, Jie Shen, Heqing Wang, Xiaoxue
Copyright Year	2015
Abstract	Chronic arsenic exposure through drinking water threatens public health worldwide. Although its multiorgan toxicity has been reported, the impact of chronic arsenic exposure on the metabolic network remains obscure. In this study, male Sprague Dawley rats were exposed to 0.5, 2 or 10 ppm sodium arsenite for three months. An ultra-high performance liquid chromatography/mass spectrometry based metabolomics approach was utilized to unveil the global metabolic response to chronic arsenic exposure in rats. Distinct serum metabolome profiles were found to be associated with the doses. Eighteen differential metabolites were identified, and most of them showed dose-dependent responses to arsenic exposure. Metabolic abnormalities mainly involved lipid metabolism and amino acid metabolism. The metabolic alterations were further confirmed by hepatic gene expression. Expressions of cpt2, lcat, cact, crot and mtr were significantly elevated in high dose groups. This study provides novel evidence to support the association between arsenic exposure and metabolic disruption, and it contributes to understanding the mechanism of chronic arsenic toxicity.
Starting Page	544
Ending Page	552
Page Count	9
File Format	HTM / HTML PDF
ISSN	17565901
Volume Number	7
Issue Number	3
Journal	Metallomics
DOI	10.1039/c5mt00002e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Metabolomics Arsenic poisoning Metabolic network Arsenic Metabolome High-performance liquid chromatography Metabolism Lecithin\u2013cholesterol acyltransferase Lipid Sprague Dawley Gene Carnitine palmitoyltransferase II Methionine synthase Sodium arsenite Mass spectrometry Public health
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Metals and Alloys Biochemistry Biomaterials Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Effects of Pu-erh tea aqueous extract (PTAE) on blood lipid metabolism enzymes

GC-MS-based metabolomics reveals mechanism of action for hydrazine induced hepatotoxicity in rats.

Serum Metabolomics in Rats after Acute Paraquat Poisoning.

Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts.

Disposition of arsenic in saliva, blood and urine of Sprague-Dawley rats following repeated oral exposure to sodium arsenite

Metabolome of canine and human saliva: a non-targeted metabolomics study.

Role of arginine, a component of aqueous garlic extract, in remediation of sodium arsenite induced toxicity in A375 cells

Serum metabolomics in rats models of ketamine abuse by gas chromatography-mass spectrometry.

Arsenic toxicity: the effects on plant metabolism

Serum metabolomics reveals that arsenic exposure disrupted lipid and amino acid metabolism in rats: a step forward in understanding chronic arsenic toxicity

Similar Documents

Effects of Pu-erh tea aqueous extract (PTAE) on blood lipid metabolism enzymes

GC-MS-based metabolomics reveals mechanism of action for hydrazine induced hepatotoxicity in rats.

Serum Metabolomics in Rats after Acute Paraquat Poisoning.

Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts.

Disposition of arsenic in saliva, blood and urine of Sprague-Dawley rats following repeated oral exposure to sodium arsenite

Metabolome of canine and human saliva: a non-targeted metabolomics study.

Role of arginine, a component of aqueous garlic extract, in remediation of sodium arsenite induced toxicity in A375 cells

Serum metabolomics in rats models of ketamine abuse by gas chromatography-mass spectrometry.

Arsenic toxicity: the effects on plant metabolism

Serum metabolomics reveals that arsenic exposure disrupted lipid and amino acid metabolism in rats: a step forward in understanding chronic arsenic toxicity